Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates.

Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates. Research Abstract Details 

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Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates. Abstract Text:

Yuansha Chen,O Colin Stine,J Glenn Morris,Judith A Johnson,Yuansha Chen,O Colin Stine,J Glenn Morris,Judith A Johnson,

Both NRT36S and A5 are NAG-ST-producing, serogroup O31 Vibrio cholerae. NRT36S is encapsulated and causes diarrhea when administered to volunteers; A5 is unencapsulated and does not colonize or cause illness in humans. The capsule/LPS (CPS/LPS) biogenesis regions in these two isolates were similar except that a 6.5-kb fragment in A5 has replaced a 10-kb fragment in NRT36S in the middle of the CPS/LPS gene cluster. Although the genes of the replaced region were homologous to genes from other CPS/LPS, they had little similarity to NRT36S and were not homologous to genes from other Vibrios. Data of this study highlight the apparent mobility within the CPS/LPS region that would provide a basis for the large number of observed V. cholerae serogroups and the emergence of novel epidemic strains.

Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates. Publishing Authors By Initials

Y Chen,OC Stine,JG Morris,JA Johnson,Y Chen,OC Stine,JG Morris,JA Johnson,

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Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEMS microbiology letters

VOLUME: 273

Page Numbers: 133-9

Journal Abbreviation: FEMS Microbiol. Lett.

ISSN: 0378-1097

DAY: 26

MONTH: Aug

YEAR: 2007

Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates. Information

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LANGUAGE: eng

NlmUniqueID: 7705721

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Grant and Affiliation Information for Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates.

AFFILIATION: University of Maryland, Baltimore, MD 21201, USA.

Country: England

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MEDLINETA: FEMS Microbiol Lett

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