Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix).

Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Research Abstract Details 

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Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Abstract Text:

Julio G Soto,Randy L Powell,Steven R Reyes,Luwam Wolana,Laura J Swanson,Elda E Sanchez,John C Perez,

Disintegrins are small, non-enzymatic proteins produced in snake venom. PCR and DNA sequencing analysis of genomic DNA for all subspecies of the copperhead snake (Agkistrodon contortrix) were analyzed for the presence of a disintegrin gene. Four samples each of the subspecies: A. c. contortrix, A. c. laticinctus, A. c. mokasen, A. c. phaeogaster, and A. c. pictigaster were collected from different locations across their geographic range and analyzed. A single PCR fragment from each sample was obtained, containing exon and intron sequences. The disintegrins identified in this study shared the highest amino acid identity to contortrostatin and acostatin b chain. Neighbor joining analysis of the disintegrin haplotypes and bootstrap tests of significance grouped the A. contortrix subspecies into two clades. The A. c. mokasen samples collected in Kentucky were grouped in one clade, while the A. c. contortrix, A. c. laticinctus, A. c. phaeogaster, and A. c. pictigaster samples collected in Texas, Louisiana, and Missouri were grouped in a different clade. Analysis of molecular variance (AMOVA) and PhiST pairwise comparisons showed significant genetic variation between subspecies. Nucleotide substitution analysis suggests the rapid evolution of disintegrin genes in A. contortrix subspecies.

Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Publishing Authors By Initials

JG Soto,RL Powell,SR Reyes,L Wolana,LJ Swanson,EE Sanchez,JC Perez,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Gene

VOLUME: 373

Page Numbers: 1-7

Journal Abbreviation: Gene

ISSN: 0378-1119

DAY: 20

MONTH: 03

YEAR: 2006

Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7706761

Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix). Information

Substance Name: Disintegrins

Registry Number: 0

Grant and Affiliation Information for Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix).

AFFILIATION: Biological Sciences Department, San Jose State University, One Washington Square, Duncan Hall 254, San Jose, CA 95192-0100, United States. jsoto3@email.sjsu.edu

Country: Netherlands

AGENCY: United States NCRR

GRANT: P40 RR018300-01

ACRONYM: RR

MEDLINETA: Gene

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