Genetic variation and human aging: progress and prospects.

Genetic variation and human aging: progress and prospects. Research Abstract Details 

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Genetic variation and human aging: progress and prospects. Abstract Text:

David Melzer,Alison J Hurst,Tim Frayling,

The genetics of aging has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory models many times over, and only evidence from humans can ultimately identify the drivers of human aging. In this article we thematically review progress in identifying human genetic variants associated with longevity. We also look at the bigger picture of progress in identifying genetic associates of disease and functioning and healthy aging in older people. Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward.

Genetic variation and human aging: progress and prospects. Publishing Authors By Initials

D Melzer,AJ Hurst,T Frayling,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Genetic variation and human aging: progress and prospects. Journal Published:

PUBLICATION TYPE: Review

Journal: The journals of gerontology. Series A, Biological

VOLUME: 62

Page Numbers: 301-7

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Mar

YEAR: 2007

Genetic variation and human aging: progress and prospects. Information

Number of References: 86

LANGUAGE: eng

NlmUniqueID: 9502837

Genetic variation and human aging: progress and prospects. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Genetic variation and human aging: progress and prospects.

AFFILIATION: Peninsula Medical School, University of Exeter, Exeter, UK. david.melzer@pms.ac.uk

Country: United States

AGENCY: United States NIA

GRANT: R01 AG24233-01

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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