Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.

Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Research Abstract Details 

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Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Abstract Text:

Anand Swaroop,Kari Eh Branham,Wei Chen,Goncalo Abecasis,Anand Swaroop,Kari Eh Branham,Wei Chen,Goncalo Abecasis,

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease, which affects quality of life for millions of elderly individuals worldwide. AMD is associated with a diverse spectrum of clinical phenotypes, all of which include the death of photoreceptors in the central part of the human retina (called the macula). Tremendous progress has been made in identifying genetic susceptibility variants for AMD. Variants at chromosome 1q32 (in the region of CFH) and 10q26 (LOC387715/ARMS2) account for a large part of the genetic risk to AMD and have been validated in numerous studies. In addition, susceptibility variants at other loci, several as yet unidentified, make substantial cumulative contribution to genetic risk for AMD; among these, multiple studies support the role of variants in APOE and C2/BF genes. Genome-wide association and re-sequencing projects, together with gene-environment interaction studies, are expected to further define the causal relationships that connect genetic variants to AMD pathogenesis and should assist in better design of prevention and intervention.

Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Publishing Authors By Initials

A Swaroop,KE Branham,W Chen,G Abecasis,A Swaroop,KE Branham,W Chen,G Abecasis,

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Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Journal Published:

PUBLICATION TYPE: Review

Journal: Human molecular genetics

VOLUME: 16 Spec No. 2

Page Numbers: R174-82

Journal Abbreviation: Hum. Mol. Genet.

ISSN: 0964-6906

DAY: 15

MONTH: Oct

YEAR: 2007

Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. Information

Number of References: 129

LANGUAGE: eng

NlmUniqueID: 9208958

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Grant and Affiliation Information for Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.

AFFILIATION: Department of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA. swaroop@umich.edu

Country: England

AGENCY: United States NEI

GRANT: EY 016862

ACRONYM: EY

MEDLINETA: Hum Mol Genet

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