Genetic studies of stuttering in a founder population.

Genetic studies of stuttering in a founder population. Research Abstract Details 

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Genetic studies of stuttering in a founder population. Abstract Text:

Jacqueline K Wittke-Thompson,Nicoline Ambrose,Ehud Yairi,Cheryl Roe,Edwin H Cook,Carole Ober,Nancy J Cox,

Genome-wide linkage and association analyses were conducted to identify genetic determinants of stuttering in a founder population in which 48 individuals affected with stuttering are connected in a single 232-person genealogy. A novel approach was devised to account for all necessary relationships to enable multipoint linkage analysis. Regions with nominal evidence for linkage were found on chromosomes 3 (P=0.013, 208.8 centiMorgans (cM)), 13 (P=0.012, 52.6 cM), and 15 (P=0.02, 100 cM). Regions with nominal evidence for association with stuttering that overlapped with a linkage signal are located on chromosomes 3 (P=0.0047, 195 cM), 9 (P=0.0067, 46.5 cM), and 13 (P=0.0055, 52.6 cM). We also conducted the first meta-analysis for stuttering using results from linkage studies in the Hutterites and The Illinois International Genetics of Stuttering Project and identified regions with nominal evidence for linkage on chromosomes 2 (P=0.013, 180-195 cM) and 5 (P=0.0051, 105-120 cM; P=0.015, 120-135 cM). None of the linkage signals detected in the Hutterite sample alone, or in the meta-analysis, meet genome-wide criteria for significance, although some of the stronger signals overlap linkage mapping signals previously reported for other speech and language disorders. EDUCATIONAL OBJECTIVES: After reading this article, the reader will be able to: (1) summarize information about the background of common disorders and methodology of genetic studies; (2) evaluate the role of genetics in stuttering; (3) discuss the value of using founder populations in genetic studies; (4) articulate the importance of combining several studies in a meta-analysis; (5) discuss the overlap of genetic signals identified in stuttering with other speech and language disorders.

Genetic studies of stuttering in a founder population. Publishing Authors By Initials

JK Wittke-Thompson,N Ambrose,E Yairi,C Roe,EH Cook,C Ober,NJ Cox,

For similar nervous system diseases: neurologic manifestations: neurobehavioral manifestations: communication disorders: language disorders: speech disorders: stuttering research abstracts see: nervous system diseases: neurologic manifestations: neurobehavioral manifestations: communication disorders: language disorders: speech disorders: stuttering research

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Genetic studies of stuttering in a founder population. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of fluency disorders

VOLUME: 32

Page Numbers: 33-50

Journal Abbreviation:

ISSN: 0094-730X

DAY: 30

MONTH: 12

YEAR: 2006

Genetic studies of stuttering in a founder population. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7601744

Genetic studies of stuttering in a founder population. Keywords Mesh Terms:

KEYWORDS: Stuttering

MESH TERMS: genetics

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Grant and Affiliation Information for Genetic studies of stuttering in a founder population.

AFFILIATION: Department of Human Genetics, The University of Chicago, Chicago, IL 60637, United States.

Country: United States

AGENCY: United States NIDCD

GRANT: R01 DC004415-04S1

ACRONYM: DC

MEDLINETA: J Fluency Disord

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