Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer.

Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Research Abstract Details 

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Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Abstract Text:

Hansjakob Müller,Martina Plasilova,Anna Marie Russell,Karl Heinimann,

Strategies of cancer prevention are generally developed with the population at large in mind. However, special attention is warranted for those persons with rare genetic traits associated with a greatly elevated risk of developing colorectal cancer (CRC) and some other malignancies: Orphan diseases demand Orphan preventive measures! Recent advances in modern genetics have enhanced our understanding of several genes and the specific germ-line mutations responsible for colorectal carcinogenesis. A number of features provide evidence for a genetic predisposition to CRC. These include typical clinical and histological features of a particular syndrome, a familial aggregation of CRC and associated malignancies, young age at onset of CRC, occurrence of multiple neoplasias and/or unusual localisation of the tumour (e.g., right side of the colon). In hereditary colorectal cancer, genetic testing can easily be demonstrated as cost-effective.

Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Publishing Authors By Initials

H Müller,M Plasilova,AM Russell,K Heinimann,

For similar proteins: neoplasm proteins research abstracts see: proteins: neoplasm proteins research

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Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 163

Page Numbers: 235-47; discussion 264-6

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 2003

Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Information

Number of References: 71

LANGUAGE: eng

NlmUniqueID: 44671

Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Neoplasm Proteins

MESH TERMS: therapy

Chemical & Substance for Abstract: Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer. Information

Substance Name: Neoplasm Proteins

Registry Number: 0

Grant and Affiliation Information for Genetic predisposition as a basis for chemoprevention, surgical and other interventions in colorectal cancer.

AFFILIATION: Research Group Human Genetics, Division of Medical Genetics UKBB, Department of Clinical-Biological Sciences, University of Basel, Vesalgasse 1, 4051 Basel, Switzerland.

Country: Germany

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MEDLINETA: Recent Results Cancer Res

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