Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy.

Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Research Abstract Details 

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Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Abstract Text:

Huiling Li,Isabelle Romieu,Hao Wu,Juan-Jose Sienra-Monge,Matiana ,Blanca Estela ,Irma Carmen ,Emily O Kistner, Gjessing,Stephanie J London,

Transforming growth factor beta-1 (TGFB1) may influence asthma by modulating allergic airway inflammation and airway remodeling. The role of single nucleotide polymorphisms (SNPs) of TGFB1 in asthma remains inconclusive. We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City. Atopy to 24 aeroallergens was determined by skin prick tests. We genotyped five TGFB1 SNPs, including two known functional SNPs [C-509T (rs1800469), T869C (rs1982073)] and three others (rs7258445, rs1800472, rs8179181), using TaqMan and Masscode assays. We analyzed the data using log-linear and polytomous logistic methods. Three associated SNPs, including the two known functional SNPs, were statistically significantly related to asthma risk. Individuals carrying the T allele of C-509T had an increased risk of asthma [relative risk (RR)=1.42, 95% confidence interval (CI)=1.08-1.87 for one copy; RR (95%CI)=1.95 (1.36-2.78) for two copies]. For T869C, the RRs (95%CI) were 1.47 (1.09-1.98) for one and 2.00 (1.38-2.90) for two copies of the C allele. Similar results were found for rs7258445. The haplotype containing all three risk alleles conferred an increased risk of asthma (RR=1.48, 95% CI=1.11-1.95 for one copy; RR=1.77, 95% CI=1.22-2.57 for two copies). These three SNPs were also related to the degree of atopy. This largest study to date of genetic variation in TGFB1 and asthma and atopy adds to increasing evidence for a role in these disorders.

Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Publishing Authors By Initials

H Li,I Romieu,H Wu,JJ Sienra-Monge,M ,BE ,IC ,EO Kistner,HK Gjessing,SJ London,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

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Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human genetics

VOLUME: 121

Page Numbers: 529-38

Journal Abbreviation:

ISSN: 0340-6717

DAY: 28

MONTH: 02

YEAR: 2007

Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7613873

Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: genetics

Chemical & Substance for Abstract: Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Information

Substance Name: Transforming Growth Factor beta1

Registry Number: 0

Grant and Affiliation Information for Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy.

AFFILIATION: Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Country: Germany

AGENCY: United States NIEHS

GRANT: Z01 ES049019-10

ACRONYM: ES

MEDLINETA: Hum Genet

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