Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.

Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Research Abstract Details 

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Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Abstract Text:

Ji-Rong Long,Qiuyin Cai,Xiao-Ou Shu,Hui Cai,Yu-Tang Gao,Wei Zheng,

BACKGROUND: Estrogen plays a central role in the development and progression of breast cancer. The estrogen's effects are at least partially regulated by estrogen-metabolizing enzymes. The objective of the study is to investigate associations of breast cancer survival with genetic polymorphisms in several genes involved in estrogen metabolism (CYP1A1, CYP1A2, CYP1B1, COMT, and AhR). METHODS: A cohort of 1140 patients aged between 25 and 64 years at the time of diagnosis for primary breast cancer during 1996-1998 were included in the study. Patients were followed for cancer recurrence and mortality through July 2005. RESULTS: Associations were observed at rs4680 (Met158Val) in the COMT gene and rs4646903 (CYP1A1*2A) in the CYP1A1 gene. The adjusted hazard ratio for the rs4680 AA genotype (low enzyme activity genotype) was 1.6 (95% confidence interval, 1.1-2.4) compared with the GG genotype for disease-free survival. Adjusted hazard ratios for the rs4646903 CC genotype were 1.6 (95% confidence interval, 1.2-2.2) for disease-free survival and 1.4 (95% confidence interval, 1.0-2.1) for overall survival compared with the TT genotype. No apparent association was found for any of the other six single nucleotide polymorphisms evaluated in the AhR, CYP1A1, CYP1A2, and CYP1B1 genes. CONCLUSION: Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be genetic markers for breast cancer prognosis in Chinese women.

Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Publishing Authors By Initials

JR Long,Q Cai,XO Shu,H Cai,YT Gao,W Zheng,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research

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MEDLINE DATE:

Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacogenetics and genomics

VOLUME: 17

Page Numbers: 331-8

Journal Abbreviation:

ISSN: 1744-6872

DAY: 3

MONTH: May

YEAR: 2007

Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101231005

Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Keywords Mesh Terms:

KEYWORDS: Receptors, Aryl Hydrocarbon

MESH TERMS: genetics

Chemical & Substance for Abstract: Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Information

Substance Name: Catechol O-Methyltransferase

Registry Number: EC 2.1.1.6

Grant and Affiliation Information for Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.

AFFILIATION: Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, S-1121 Medical Center North, Nashville, TN 37232, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 90899

ACRONYM: CA

MEDLINETA: Pharmacogenet Genomics

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