Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela.

Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Research Abstract Details 

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Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Abstract Text:

Ikuko Kato,Federico Canzian,Silvia Franceschi,Martyn Plummer,Leen-Jan van Doorn,Yanhui Lu,Lydie Gioia-Patricola,Jorge Vivas,Gladys Lopez,Richard K Severson,Ann G Schwartz,Nubia ,

OBJECTIVES: The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors. METHODS: The study population consisted of 2,033 Venezuelan subjects known to have extremely high Helicobacter Pylori (HP) infection rates. The odds ratios (OR) and 95% confidence intervals (CI) associated with these polymorphisms were estimated by multinominal logistic regression models for gastric precursor lesions. RESULTS: We found a 60% increase in risk of intestinal metaplasia (IM) and dysplasia combined (OR 1.62, 95% CI: 1.10-2.38) among the carriers of the IL10-1082 low activity allele. This increased risk was more pronounced for dysplasia than for IM. On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05-2.21), compared with homozygotes of the high activity allele. There were no statistically significant synergetic interactions between these polymorphisms and environmental risk factors (low fruit intake, high starchy vegetable intake and cigarette smoking) for these lesions. CONCLUSION: While the results of the present study suggest roles of genetic variability in these anti-inflammatory mediators in different stages of gastric carcinogenesis, there is high likelihood that they were chance findings due to multiple comparisons.

Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Publishing Authors By Initials

I Kato,F Canzian,S Franceschi,M Plummer,LJ van Doorn,Y Lu,L Gioia-Patricola,J Vivas,G Lopez,RK Severson,AG Schwartz,N ,

For similar geographic locations: americas: south america: venezuela research abstracts see: geographic locations: americas: south america: venezuela research

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Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer causes & control : CCC

VOLUME: 17

Page Numbers: 1183-91

Journal Abbreviation: Cancer Causes Control

ISSN: 0957-5243

DAY: 3

MONTH: Nov

YEAR: 2006

Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100846

Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Keywords Mesh Terms:

KEYWORDS: Venezuela

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela. Information

Substance Name: Interleukin-4

Registry Number: 207137-56-2

Grant and Affiliation Information for Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela.

AFFILIATION: Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA. katoi@med.wayne.edu

Country: Netherlands

AGENCY: United States NCI

GRANT: CA 98309

ACRONYM: CA

MEDLINETA: Cancer Causes Control

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