[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer]

[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer] Research Abstract Details 

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[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer] Abstract Text:

Tomiyasu Arisawa,Ichiro Hirata,Tomiyasu Arisawa,Ichiro Hirata,Tomiyasu Arisawa,Ichiro Hirata,

Cyclooxygenase-1(COX-1) has traditionally been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. The effects of non-steroidal anti-inflammatory drug(NSAID) on the gastric mucosal damage are caused by the inhibition of this enzyme. Although A-842G in the COX-1 gene promoter was reported as a functional polymorphism, we could not detect this polymorphism in Japanese population. However, T-1676C polymorphism (rs1330344) was significantly associated with the development of peptic ulcer, especially gastric ulcer. In addition, rs1330344 was also significantly associated with the development of NSAID-induced ulcer diseases. In conclusions, the assessment for genotype of COX-1 gene promoter polymorphism, especially rs1330344, may be useful for detecting the high risk group of developing NSAID-induced ulcer diseases.

[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer] Publishing Authors By Initials

T Arisawa,I Hirata,T Arisawa,I Hirata,T Arisawa,I Hirata,

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[Genetic polymorphism of COX-1 gene and NSAID-induced ulcer] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nippon rinsho. Japanese journal of clinical medici

VOLUME: 65

Page Numbers: 1885-9

Journal Abbreviation: Nippon Rinsho

ISSN: 0047-1852

DAY: 10

MONTH: Oct

YEAR: 2007

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LANGUAGE: jpn

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AFFILIATION: Department of Gastroenterology, Fujita Health University.

Country: Japan

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MEDLINETA: Nippon Rinsho

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