Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.

Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Research Abstract Details 

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Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Abstract Text:

Sungha Park,Jong-Chan Youn,Dong-Jik Shin,Chan-Mi Park,Jung-Sun Kim,Young-Guk Ko,Donghoon Choi,Jong-Won Ha,Yangsoo Jang,Namsik Chung,Sungha Park,Jong-Chan Youn,Dong-Jik Shin,Chan-Mi Park,Jung-Sun Kim,Young-Guk Ko,Donghoon Choi,Jong-Won Ha,Yangsoo Jang,Namsik Chung,

BACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is a high-molecular-weight, zinc-binding matrix metalloproteinase that is known to be abundantly expressed in ruptured plaques. Previous studies have shown PAPP-A to be a significant marker of plaque instability and cardiovascular events in patients with acute coronary syndromes. Because the activity of PAPP-A may be modulated by genetic variants in the PAPP-A genes, we tried to determine the association of PAPP-A gene with acute myocardial infarction (AMI). METHODS: We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively. RESULTS: The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015). CONCLUSIONS: We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals.

Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Publishing Authors By Initials

S Park,JC Youn,DJ Shin,CM Park,JS Kim,YG Ko,D Choi,JW Ha,Y Jang,N Chung,S Park,JC Youn,DJ Shin,CM Park,JS Kim,YG Ko,D Choi,JW Ha,Y Jang,N Chung,

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Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Coronary artery disease

VOLUME: 18

Page Numbers: 417-22

Journal Abbreviation: Coron. Artery Dis.

ISSN: 0954-6928

DAY: 16

MONTH: Sep

YEAR: 2007

Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.

AFFILIATION: Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Shinchon-Dong, Seodaemun-Ku, Seoul, Republic of Korea.

Country: England

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MEDLINETA: Coron Artery Dis

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