Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae.

Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Research Abstract Details 

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Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Abstract Text:

S Bygdeman,M Bäckman,D Danielsson,M Norgren,

In previous works statistically significant differences were demonstrated in antibiotic susceptibility between gonococcal strains of the recently described W serogroups, W I, W II and W III, respectively. Strains of serogroup W I were almost always sensitive to penicillin and other antibiotics while those of the W II and W III serogroups showed a higher incidence of decreased susceptibility. Transformation experiments were therefore undertaken with an antibiotic sensitive serogroup W I gonococcal strain as recipient and a multi-resistant W II strain as DNA-donor. Transformants, with increased resistance to penicillin and several other antibiotics as compared with the recipient, acquired the same serogroup specificity as the W II donor. With one of these W II transformants as donor and the sensitive W I strain as recipient all transformants acquired the same antibiotic susceptibility pattern as well as the same serogroup as the donor. SDS-PAGE, performed on sarkosyl extracted outer membrane proteins from donor, recipient and some transformants, showed an increase in the molecular weight of the Protein I of the outer membrane of the W II transformants as compared with that of the recipient strain. In rocket-line and crossed-line immunoelectrophoresis the W II transformants could not be distinguished from the W II donor strain. A genetic linkage between antibiotic multi-resistance and serogroup W II specificity was thus shown. This is in agreement with the demonstrated higher incidence of W II strains with increased antibiotic resistance as compared with that of serogroup W I strains.

Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Publishing Authors By Initials

S Bygdeman,M Bäckman,D Danielsson,M Norgren,

For similar genetic processes: recombination, genetic: transformation, genetic research abstracts see: genetic processes: recombination, genetic: transformation, genetic research

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Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 90

Page Numbers: 243-50

Journal Abbreviation:

ISSN: 0108-0180

DAY: 12

MONTH: Jun

YEAR: 1982

Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Information

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LANGUAGE: eng

NlmUniqueID: 8206623

Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Keywords Mesh Terms:

KEYWORDS: Transformation, Genetic

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae. Information

Substance Name: Penicillins

Registry Number: 0

Grant and Affiliation Information for Genetic linkage between serogroup specificity and antibiotic resistance in Neisseria gonorrhoeae.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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