[Genetic heterogeneity for familial recurrent hydatidiform mole]

[Genetic heterogeneity for familial recurrent hydatidiform mole] Research Abstract Details 

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[Genetic heterogeneity for familial recurrent hydatidiform mole] Abstract Text:

Jun Zhao,Yang Xiang,Shang-zhi Huang,Xi-run Wan,Quan-cai Cui,M J Seckl,R A Fisher,

OBJECTIVE: To determine the parental origin of the genome in the molar pregnancies of two familes with familial recurrent hydatidiform mole (FRHM) and to investigate whether the gene responsible for FRHM is likely to be located within the 19q13.4 region in these familes. METHODS: The features of complete hydatidiform mole (CHM) were confirmed by pathological examination. DNA of CHM was prepared from sections of formalin-fixed paraffin-embedded blocks of molar tissue following laser capture microdissection. The polymerace chain reaction was used to amplify microsatellite polymorphisms in DNA from the patients, their husbands and the captured molar tissue. Parental contributions to the molar tissue were determined using ABI 310 GeneScan software. Genotyping and haplotype analysis of the candidate region on 19q13.4 was performed for members of both families using 25 microsatellite markers. RESULTS: One CHM from each family was identified as a biparental complete hydatidiform mole. All patients were heterozygous for most of the markers in the chromosome region of interest. In addition the two affected sisters in one of the families had different genotypes for the 19q13.4 region, suggesting that mutations in a different locus might be responsible for the disorder in this family. CONCLUSION: The location of the gene responsible for FRHM is unlikely to be located in the 19q13.4 chromosomal region in these two families suggesting that FRHM shows genetic heterogeneity.

[Genetic heterogeneity for familial recurrent hydatidiform mole] Publishing Authors By Initials

J Zhao,Y Xiang,SZ Huang,XR Wan,QC Cui,MJ Seckl,RA Fisher,

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[Genetic heterogeneity for familial recurrent hydatidiform mole] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 23

Page Numbers: 511-4

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 9

MONTH: Oct

YEAR: 2006

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LANGUAGE: chi

NlmUniqueID: 9425197

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Grant and Affiliation Information for [Genetic heterogeneity for familial recurrent hydatidiform mole]

AFFILIATION: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, 100730 PR China.

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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