Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia.

Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Research Abstract Details 

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Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Abstract Text:

Mizuho Takeshita,Kazuo Yamada,Eiji Hattori,Yoshimi Iwayama,Tomoko Toyota,Yasuhide Iwata,Kenji J Tsuchiya,Genichi Sugihara,Kenji Hashimoto,Hiroyuki Watanabe,Masaomi Iyo,Mitsuru Kikuchi,Yuji Okazaki,Takeo Yoshikawa,Mizuho Takeshita,Kazuo Yamada,Eiji Hattori,Yoshimi Iwayama,Tomoko Toyota,Yasuhide Iwata,Kenji J Tsuchiya,Genichi Sugihara,Kenji Hashimoto,Hiroyuki Watanabe,Masaomi Iyo,Mitsuru Kikuchi,Yuji Okazaki,Takeo Yoshikawa,

Aberrant neuronal development is one of the integrative theories for the etiology of schizophrenia. The plexin A2 (PLXNA2) gene is one of the receptor genes for axonal guidance factors. Recently, four single nucleotide polymorphisms (SNPs), rs841865, rs752016, rs1327175 and rs2498028, from the PLXNA2 genomic interval have been reported to be associated with schizophrenia in samples from European Americans, Latin Americans and Asian Americans. We tested these four SNPs for association with disease in two Asian populations: 1140 case-control Japanese samples and 293 Chinese pedigrees (1163 samples). In the Japanese samples, significant differences in the allelic frequency and genotypic distribution of rs841865 (p=0.019 and 0.020, respectively) were observed between cases and controls. Haplotype analysis also revealed a significant association of the gene with the disease (global p=0.028). In contrast, there was no genetic contribution of PLXNA2 to Chinese schizophrenia, either by linkage analysis or association tests (allelic and haplotypic transmission disequilibrium tests). These findings suggest that PLXNA2 confers a varying genetic risk for schizophrenia among different populations.

Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Publishing Authors By Initials

M Takeshita,K Yamada,E Hattori,Y Iwayama,T Toyota,Y Iwata,KJ Tsuchiya,G Sugihara,K Hashimoto,H Watanabe,M Iyo,M Kikuchi,Y Okazaki,T Yoshikawa,M Takeshita,K Yamada,E Hattori,Y Iwayama,T Toyota,Y Iwata,KJ Tsuchiya,G Sugihara,K Hashimoto,H Watanabe,M Iyo,M Kikuchi,Y Okazaki,T Yoshikawa,

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Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Schizophrenia research

VOLUME: 99

Page Numbers: 359-64

Journal Abbreviation: Schizophr. Res.

ISSN: 0920-9964

DAY: 11

MONTH: 12

YEAR: 2007

Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan; Department of Paediatrics, Tokyo Medical University, Tokyo 160-0023, Japan.

Country: Netherlands

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MEDLINETA: Schizophr Res

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