Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation.

Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Research Abstract Details 

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Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Abstract Text:

Matthew Cabral,Christophe Anjard,William F Loomis,Adam Kuspa,

The acyl coenzyme A (CoA) binding protein AcbA is cleaved to form a peptide (SDF-2) that coordinates spore encapsulation during the morphogenesis of Dictyostelium discoideum fruiting bodies. We present genetic evidence that the misspecification of cell types seen in mutants of the serine protease/ABC transporter TagA results from the loss of normal interactions with AcbA. Developmental phenotypes resulting from aberrant expression of the TagA protease domain, such as the formation of supernumerary tips on aggregates and the production of excess prestalk cells, are suppressed by null mutations in the acbA gene. Phenotypes resulting from the deletion of tagA, such as overexpression of the prestalk gene ecmB and the misexpression of the prespore gene cotB in stalk cells, are also observed in acbA mutants. Moreover, tagA- mutants fail to produce SDF-2 during fruiting body morphogenesis but are able to do so if they are stimulated with exogenous SDF-2. These results indicate that the developmental program depends on TagA and AcbA working in concert with each other during cell type differentiation and suggest that TagA is required for normal SDF-2 signaling during spore encapsulation.

Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Publishing Authors By Initials

M Cabral,C Anjard,WF Loomis,A Kuspa,

For similar cells: spores: spores, protozoan research abstracts see: cells: spores: spores, protozoan research

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Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Eukaryotic cell

VOLUME: 5

Page Numbers: 2024-32

Journal Abbreviation: Eukaryotic Cell

ISSN: 1535-9778

DAY: 20

MONTH: 10

YEAR: 2006

Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130731

Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Keywords Mesh Terms:

KEYWORDS: Spores, Protozoan

MESH TERMS: metabolism

Chemical & Substance for Abstract: Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation. Information

Substance Name: Serine Endopeptidases

Registry Number: EC 3.4.21.-

Grant and Affiliation Information for Genetic evidence that the acyl coenzyme A binding protein AcbA and the serine protease/ABC transporter TagA function together in Dictyostelium discoideum cell differentiation.

AFFILIATION: Department of Molecular and Human Genetics, Baylor College of Medicine, Mail Station 356A, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R25GM56929

ACRONYM: GM

MEDLINETA: Eukaryot Cell

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