Genetic diversity of Bartonella henselae in human infection detected with multispacer typing.

Genetic diversity of Bartonella henselae in human infection detected with multispacer typing. Research Abstract Details 

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Genetic diversity of Bartonella henselae in human infection detected with multispacer typing. Abstract Text:

Wenjun Li,Didier Raoult,Pierre-Edouard Fournier,Wenjun Li,Didier Raoult,Pierre-Edouard Fournier,

We applied multispacer typing (MST) by incorporating 9 variable intergenic spacers to Bartonella henselae DNA detected in lymph node biopsy specimens from 70 patients with cat-scratch disease (CSD), in cardiac valve specimens from 2 patients with endocarditis, and in 3 human isolates from patients with bacillary angiomatosis, CSD, and endocarditis. Sixteen MST genotypes were found, 5 previously identified in cats and 11 new. Of the studied DNA, 78.7% belonged to 2 genotypes, which were phylogenetically organized into 4 lineages. Human strains were mostly grouped within 2 lineages, previously identified as Marseille and Houston-1. Our results suggest a greater genetic diversity in human-infecting B. henselae than what has previously been evaluated by using other genotyping methods. However, the diversity is not significantly different from that of cat strains. MST is thus a suitable genotyping tool for evaluating the genetic heterogeneity of B. henselae among isolates obtained from human patients.

Genetic diversity of Bartonella henselae in human infection detected with multispacer typing. Publishing Authors By Initials

W Li,D Raoult,PE Fournier,W Li,D Raoult,PE Fournier,

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Genetic diversity of Bartonella henselae in human infection detected with multispacer typing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Emerging infectious diseases

VOLUME: 13

Page Numbers: 1178-83

Journal Abbreviation: Emerging Infect. Dis.

ISSN: 1080-6040

DAY: 23

MONTH: Aug

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Université de la Méditerraneé, Marseille, France.

Country: United States

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MEDLINETA: Emerg Infect Dis

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