The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P=0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h2) was estimated to be 0.618 (P=0.09). In addition, the h2 derived from the variance component model implemented in SOLAR was 0.722 (P<0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.
Genetic determination in onset age of wrist fracture. Publishing Authors By Initials
Genetic determination in onset age of wrist fracture. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Journal of human genetics
VOLUME: 52
Page Numbers: 481-4
Journal Abbreviation: J. Hum. Genet.
ISSN: 1434-5161
DAY: 25
MONTH: 04
YEAR: 2007
Genetic determination in onset age of wrist fracture. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 9808008
Genetic determination in onset age of wrist fracture. Keywords Mesh Terms:
KEYWORDS: Wrist Injuries
MESH TERMS: genetics
Chemical & Substance for Abstract: Genetic determination in onset age of wrist fracture. Information
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Grant and Affiliation Information for Genetic determination in onset age of wrist fracture.
AFFILIATION: The Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.
Country: Japan
AGENCY: United States NIGMS
GRANT: R01 GM60402-01A1
ACRONYM: GM
MEDLINETA: J Hum Genet
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