Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Abstract Text:

Stefano Marenco,Michael A Siuta,J Shane Kippenhan,Samuel Grodofsky,Wei-Li Chang,Philip Kohn,Carolyn B Mervis,Colleen A Morris,Daniel R Weinberger,Andreas Meyer-Lindenberg,Carlo Pierpaoli,Karen Faith Berman,

Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation.

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Publishing Authors By Initials

S Marenco,MA Siuta,JS Kippenhan,S Grodofsky,WL Chang,P Kohn,CB Mervis,CA Morris,DR Weinberger,A Meyer-Lindenberg,C Pierpaoli,KF Berman,

For similar nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation: williams syndrome research abstracts see: nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation: williams syndrome research

PUBMED ID PMID:

MEDLINE DATE:

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 15117-22

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 7

MONTH: 09

YEAR: 2007

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Keywords Mesh Terms:

KEYWORDS: Williams Syndrome

MESH TERMS: pathology

Chemical & Substance for Abstract: Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome. Information

Substance Name: Lim Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.

AFFILIATION: Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. marencos@mail.nih.gov

Country: United States

AGENCY: United States NINDS

GRANT: NS35102

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome Related Publications

• A 60-year-old woman considering acupuncture for knee pain.
• A rare case of primary lung adenocarcinoma detected by routine liquid-based cervical cytology.
• A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network.
• Added value of rest to stress study for recognition of artifacts in perfusion cardiovascular magnetic resonance.
• Addiction writer could have made his point without theologic comments.
• Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women.
• Anti-hyperalgesic and Anti-inflammatory Effects of the Modified Chinese Herbal Formula Huo Luo Xiao Ling Dan (HLXL) in Rats.
• Anxiety sensitivity and retaliatory aggressive behavior in research volunteers.
• Breast Tissue Density and CAD Cancer Detection in Digital Mammography.
• Comparing models of helper behavior to actual practice in telephone crisis intervention: a Silent Monitoring Study of Calls to the U.S. 1-800-SUICIDE Network.
• Complex, multimodal behavioral profile of the Homer1 knockout mouse.
• Continuity, the medical home, and retail-based clinics.
• Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS.
• Extending the potential of evaporative cooling for heat-stress relief.
• Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes.
• Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome.
• Meta-analysis: acupuncture for osteoarthritis of the knee.
• Misperceptions regarding influenza vaccine safety for individuals with chronic medical illness.
• Morphogenesis and cell cycle progression in Candida albicans.
• Neural mechanisms of proactive interference-resolution.
• Nurse staffing and adverse events in hospitalized children.
• Open system of interacting fermions: statistical properties of cross sections and fluctuations.
• Playing catch in the park.
• Recent advances in breast-specific imaging.
• Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis.
• State strategies to reduce the number of uninsured children.
• Statistical Analysis of X-ray Speckle at the NSLS.
• Steep restitution of ventricular action potential duration and conduction slowing in human Brugada syndrome.
• Toxicity of commonly-used antimalarial drugs.
• Which helper behaviors and intervention styles are related to better short-term outcomes in telephone crisis intervention? Results from a Silent Monitoring Study of Calls to the U.S. 1-800-SUICIDE Network.