[Genetic basis of ankylosing spondylitis]

[Genetic basis of ankylosing spondylitis] Research Abstract Details 

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[Genetic basis of ankylosing spondylitis] Abstract Text:

F Pimentel dos Santos,E Bastos,D Ligeiro,A F ,R Chaves,H Trindade,H Guedes-Pinto,J C Branco,F Pimentel dos Santos,E Bastos,D Ligeiro,A F ,R Chaves,H Trindade,H Guedes-Pinto,J C Branco,F Pimentel dos Santos,E Bastos,D Ligeiro,A F ,R Chaves,H Trindade,H Guedes-Pinto,J C Branco,

Ankylosing spondylitis (AS) is a common rheumatic condition, highly heritable. Much of the genetic contribution to the disease lies in the major histocompatibility complex (MHC). The association with the allele group HLA-B*27 has been described worldwide for 30 years. On the other hand, genome wide scans have provided some interesting results showing that other MHC and non-MHC genes could be implicated either in disease susceptibility and phenotypic manifestations. Different hypothesis for disease pathophysiology have been investigated which contribute for a better understanding of the genetic basis of AS. This review aims to summarize the status of the knowledge in this exciting area. New data may, in a near future, change the screening of patients and generate new insights for the emergence of novel therapies.

[Genetic basis of ankylosing spondylitis] Publishing Authors By Initials

FP Santos,E Bastos,D Ligeiro,AF ,R Chaves,H Trindade,H Guedes-Pinto,JC Branco,FP Santos,E Bastos,D Ligeiro,AF ,R Chaves,H Trindade,H Guedes-Pinto,JC Branco,FP Santos,E Bastos,D Ligeiro,AF ,R Chaves,H Trindade,H Guedes-Pinto,JC Branco,

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PUBMED ID PMID:

MEDLINE DATE: 2007 Jul-Sep

[Genetic basis of ankylosing spondylitis] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta reumatológica portuguesa

VOLUME: 32

Page Numbers: 243-52

Journal Abbreviation:

ISSN: 0303-464X

DAY: 11

MONTH: 10

YEAR: 2007

[Genetic basis of ankylosing spondylitis] Information

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LANGUAGE: por

NlmUniqueID: 431702

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Grant and Affiliation Information for [Genetic basis of ankylosing spondylitis]

AFFILIATION: Serviço de Reumatologia do CHLO EPE, Hospital de Egas Moniz, Lisbon. pimentel.santos@gmail.com

Country: Portugal

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MEDLINETA: Acta Reumatol Port

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