Genetic basis for the new pneumococcal serotype, 6C.

Genetic basis for the new pneumococcal serotype, 6C. Research Abstract Details 

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Genetic basis for the new pneumococcal serotype, 6C. Abstract Text:

In Ho Park,Saeyoung Park,Susan K Hollingshead,Moon H Nahm,

We have recently reported a new pneumococcal serotype (6C), which is closely related to serotype 6A (I. H. Park et al., J. Clin. Microbiol. 45:1225-1233, 2007). To investigate the genetic basis for serotype 6C, we studied the capsule gene loci of 14 6C isolates from three different continents, including one isolated in Alabama 27 years ago. The wciN region of all 6C isolates has a 1,029-bp-long sequence that replaces the 1,222-bp-long sequence of the 6A wciN region. This recombination event has created a new 1,125-bp-long open reading frame which encodes a product that is also homologous to glycosyl transferases. Flanking this introduced gene is 300 bp upstream and 100 bp downstream with only about 90% homology with 6A and which is identical in all 6C isolates. Transfer of the wciN region converts 6A to 6C. Determination of the DNA sequence of the entire capsule gene locus of one 6C isolate showed that the 6C capsule gene locus is almost identical (>98% homologous) to that of 6A except for the wciN region. These findings indicate that the 6C capsule type originated more than 27 years ago by a single recombination event in a 6A locus in which 6A wciN was replaced by a gene of unknown origin.

Genetic basis for the new pneumococcal serotype, 6C. Publishing Authors By Initials

IH Park,S Park,SK Hollingshead,MH Nahm,

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research

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Genetic basis for the new pneumococcal serotype, 6C. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 4482-9

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 18

MONTH: 06

YEAR: 2007

Genetic basis for the new pneumococcal serotype, 6C. Information

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LANGUAGE: eng

NlmUniqueID: 246127

Genetic basis for the new pneumococcal serotype, 6C. Keywords Mesh Terms:

KEYWORDS: Streptococcus pneumoniae

MESH TERMS: immunology

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Grant and Affiliation Information for Genetic basis for the new pneumococcal serotype, 6C.

AFFILIATION: Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, BBRB 614, Birmingham, AL 35294, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI-30021

ACRONYM: AI

MEDLINETA: Infect Immun

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