Genetic approaches to polycystic ovarian syndrome.

Genetic approaches to polycystic ovarian syndrome. Research Abstract Details 

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Genetic approaches to polycystic ovarian syndrome. Abstract Text:

Marie Nam Menke,Jerome F Strauss,

PURPOSE OF REVIEW: This review clarifies the challenges facing investigators in the search for polycystic ovarian syndrome candidate genes. RECENT FINDINGS: Evidence for fibillin 3 has emerged as a polycystic ovarian syndrome candidate gene. The sex hormone binding gene also shows promise, as does evidence for fetal programming and X-chromosome inactivation. SUMMARY: As with many complex disorders, the heritability of polycystic ovarian syndrome has eluded investigators. Although familial aggregation studies have demonstrated clearly a genetic component to the syndrome, simple Mendelian models do not characterize its mode of inheritance. Instead, multiple loci and epigenetic modification may play a role in the phenotype. The candidate gene approach relies upon improved statistical and technological methods to analyze potential genes based on biologic plausibility. Pathways that affect steroidogenesis, insulin resistance, gonadotropin function, and obesity provide potential genes for investigation. Obstacles such as phenotypic variability, lack of a male phenotype, multiple attempts at analysis, and small sample sizes hamper these efforts. Nevertheless, great care must be taken to apply rigorous standards as we proceed with genetic studies. In addition to increasing our knowledge of common disorders, potential benefits include personalized medicine, with pharmacogenetics allowing therapies tailored to the individual.

Genetic approaches to polycystic ovarian syndrome. Publishing Authors By Initials

MN Menke,JF Strauss,

For similar neoplasms: cysts: ovarian cysts: polycystic ovary syndrome research abstracts see: neoplasms: cysts: ovarian cysts: polycystic ovary syndrome research

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Genetic approaches to polycystic ovarian syndrome. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in obstetrics & gynecology

VOLUME: 19

Page Numbers: 355-9

Journal Abbreviation: Curr. Opin. Obstet. Gynecol.

ISSN: 1040-872X

DAY: 3

MONTH: Aug

YEAR: 2007

Genetic approaches to polycystic ovarian syndrome. Information

Number of References: 40

LANGUAGE: eng

NlmUniqueID: 9007264

Genetic approaches to polycystic ovarian syndrome. Keywords Mesh Terms:

KEYWORDS: Polycystic Ovary Syndrome

MESH TERMS: genetics

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Grant and Affiliation Information for Genetic approaches to polycystic ovarian syndrome.

AFFILIATION: Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. mmenke@mcvh-vcu.edu

Country: England

AGENCY: United States NICHD

GRANT: U54 HD034449

ACRONYM: HD

MEDLINETA: Curr Opin Obstet Gynecol

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