Genetic approaches to complications of prematurity.

Genetic approaches to complications of prematurity. Research Abstract Details 

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Genetic approaches to complications of prematurity. Abstract Text:

Haiying Meng,Jeffrey R Gruen,

Over the last 15 years neonatal morbidity and mortality have changed little for very low birth weight (VLBW) babies despite significant technological and therapeutic advances. While clinical trials and animal models have until recently improved outcomes in this gestational age group, further productivity from these traditional sources are not likely. A recent study of monozygotic and dizygotic twins shows that the main determinants of neonatal morbidity and mortality in VLBW babies--bronchopulmonary dysplasia, necrotizing enterocolitis, and intraventricular hemorrhage--have significant genetic components. Incremental improvements in the future, therefore, will likely depend on identification of these genetic components for targeting specific therapies. Cost-effective methods and resources, fueled by the Human Genome and HapMap Projects and recent successes in identifying genes for a small number of complex genetic diseases, are available now and through creative planning and timely implementation would likely yield useful results.

Genetic approaches to complications of prematurity. Publishing Authors By Initials

H Meng,JR Gruen,

For similar genetic phenomena: linkage (genetics) research abstracts see: genetic phenomena: linkage (genetics) research

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Genetic approaches to complications of prematurity. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 2344-51

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2007

Genetic approaches to complications of prematurity. Information

Number of References: 30

LANGUAGE: eng

NlmUniqueID: 9709506

Genetic approaches to complications of prematurity. Keywords Mesh Terms:

KEYWORDS: Linkage (Genetics)

MESH TERMS: genetics

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Grant and Affiliation Information for Genetic approaches to complications of prematurity.

AFFILIATION: Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS43530

ACRONYM: NS

MEDLINETA: Front Biosci

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