Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice.

Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Research Abstract Details 

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Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Abstract Text:

Khyobeni Mozhui,Kristin M Hamre,Andrew Holmes,Lu Lu,Robert W Williams,

The amygdala integrates and coordinates emotional and autonomic responses. The genetics that underlie variation in amygdala structure may be coupled to variation in levels of aggression, fear, anxiety, and affiliated behaviors. We systematically quantified the volume and cell populations of the basolateral amygdala complex (BLAc) across 35 BXD recombinant inbred (RI) lines, the parental strains--C57BL/6J (B6) and DBA/2J (D2)--and F1 hybrids (n cases=199, bilateral analysis). Neuron number and volume vary 1.7- to 2-fold among strains (e.g., neuron number ranged from 88,000 to 170,000). Glial and endothelial populations ranged more widely (5- to 8-fold), in part because of higher technical error. A quantitative trait locus (QTL) for the BLAc size is located on chromosome (Chr) 8 near the Large gene. This locus may also influence volume of other regions including hippocampus and cerebellum. Cell populations in the BLAc appear to be modulated more weakly by loci on Chrs 11 and 13. Candidate genes were selected on the basis of correlation with BLAc traits, chromosomal location, single nucleotide polymorphism (SNP) density, and expression patterns in the Allen Brain Atlas. Neurod2, a gene shown to be significant for the formation of the BLAc by knockout studies, is among the candidates genes. Other candidates include Large, and Thra. Responses to drugs of abuse and locomotor activity were the most notable behavioral correlates of the BLAc traits.

Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Publishing Authors By Initials

K Mozhui,KM Hamre,A Holmes,L Lu,RW Williams,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Behavior genetics

VOLUME: 37

Page Numbers: 223-43

Journal Abbreviation: Behav. Genet.

ISSN: 0001-8244

DAY: 28

MONTH: 11

YEAR: 2006

Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Information

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LANGUAGE: eng

NlmUniqueID: 251711

Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: physiology

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Grant and Affiliation Information for Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice.

AFFILIATION: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA.

Country: United States

AGENCY: United States NIAAA

GRANT: U24AA13513

ACRONYM: AA

MEDLINETA: Behav Genet

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