Genetic and genomic approaches to studying stature and pubertal timing.

Genetic and genomic approaches to studying stature and pubertal timing. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Genetic and genomic approaches to studying stature and pubertal timing. Abstract Text:

Stature and puberal timing are two complex genetic traits that vary widely within a population due to a combination of genetic and environmental factors. Rare mutations explain a fraction of severe short stature, but rare mutations are less likely to explain most of idiopathic short stature or most of the population variation in height or the timing of puberty. In this review, we discuss how association and linkage studies, in conjunction with new genomic technologies, will allow researchers to survey genes for the variants that underlie these traits. For both association and linkage studies to be successful, large samples and careful interpretation are critical.

Genetic and genomic approaches to studying stature and pubertal timing. Publishing Authors By Initials

For similar genetic phenomena: inheritance patterns: quantitative trait, heritable research abstracts see: genetic phenomena: inheritance patterns: quantitative trait, heritable research

PUBMED ID PMID:

MEDLINE DATE:

Genetic and genomic approaches to studying stature and pubertal timing. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric endocrinology reviews : PER

VOLUME: 2 Suppl 3

Page Numbers: 351-4

Journal Abbreviation:

ISSN: 1565-4753

DAY: 9

MONTH: Feb

YEAR: 2005

Genetic and genomic approaches to studying stature and pubertal timing. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 101202124

Genetic and genomic approaches to studying stature and pubertal timing. Keywords Mesh Terms:

KEYWORDS: Quantitative Trait, Heritable

MESH TERMS: genetics

Chemical & Substance for Abstract: Genetic and genomic approaches to studying stature and pubertal timing. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Genetic and genomic approaches to studying stature and pubertal timing.

AFFILIATION: Children's Hospital/Harvard Medical School, Boston, MA 02115, USA. joelh@childrens.harvard.edu

Country: Israel

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Endocrinol Rev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Genetic and genomic approaches to studying stature and pubertal timing Related Publications

• Adenosine deaminase deficiency.
• Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.
• Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.
• Cytogenetic and immunologic abnormalities related to leukemia.
• Discerning the ancestry of European americans in genetic association studies.
• Genetic and genomic approaches to studying stature and pubertal timing.
• Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
• Genome-wide association studies: past, present and future.
• Genome-wide association studies: potential next steps on a genetic journey.
• Healthcare epidemiology: hospital staffing and health care-associated infections: a systematic review of the literature.
• Identification of an RsaI RFLP at the acid alpha glucosidase (GAA) locus.
• Identification of ten loci associated with height highlights new biological pathways in human growth.
• Multiple hemangiomas in a patient with a t(3q;4p) translocation: an infrequent association with Wolf-Hirschhorn syndrome.
• Role of inactivity in production of disease; hypokinetic disease.
• The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
• The management of acute diarrhea in children: an overview.