Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Research Abstract Details 

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Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Abstract Text:

Chris A Learn,Peter M Grossi,Robert J Schmittling,Weihua Xie,Duane A Mitchell,Isaac Karikari,ZhengZheng Wei,Holly Dressman,John H Sampson,

For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA microarray analysis of autologous normal murine astroctyes (NMA) and SMA-560 tumor cells grown in monolayer culture or intracranially in syngeneic immunocompetent or immunocompromised hosts in order to determine whether tumors grown in vitro recreate the complex genetic regulation that occurs in vivo. Our findings support our hypothesis that glioma phenotype in vitro may be quite different in vivo and significantly altered by in situ growth factors and other invading cell populations.

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Publishing Authors By Initials

CA Learn,PM Grossi,RJ Schmittling,W Xie,DA Mitchell,I Karikari,Z Wei,H Dressman,JH Sampson,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimmunology

VOLUME: 182

Page Numbers: 63-72

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 29

MONTH: 11

YEAR: 2006

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: pathology

Chemical & Substance for Abstract: Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. Information

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Grant and Affiliation Information for Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

AFFILIATION: Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States.

Country: Netherlands

AGENCY: United States NCI

GRANT: R01 CA097222-05

ACRONYM: CA

MEDLINETA: J Neuroimmunol

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