Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006.

Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006. Research Abstract Details 

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Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006. Abstract Text:

Haesun Yun,Soyeon Kim,Hyeokjin Lee,Kwan Soo Byun,So Young Kwon,Hyung Joon Yim,Young-Suk Lim,Sook-Hyang Jeong,Youngmee Jee,

Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in Korea, the VP3/VP1 and VP1/P2A junction regions were detected by RT-PCR from HAV IgM positives during 2005 and 2006. Among 160 HAV IgM positive sera, 30% (n = 48) were positive for HAV RNA. Additionally, the VP3/VP1 junction regions were detected all six stools, which collected from outbreak in Gyeonggi province. Phylogenetic analysis of the sequences obtained from 54 distinct HAV isolates revealed that most of the strains (n = 45) belonged to genotype IA and the others including nine strains belonged to genotype IIIA. Interestingly, a Q --> S amino acid change was dominantly observed at position 810 of the VP1/P2A junction region in 14 isolates. The molecular epidemiology of HAV infection in Korea has changed with the co-circulation of at least two genotypes and 810Q --> S amino acid substitutions were found to be prevalent. These results strongly suggest that various HAV strains, including genotype IIIA, might be imported from high-endemic countries into Korea. J. Med. Virol. 80:777-784, 2008. (c) 2008 Wiley-Liss, Inc.

Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006. Publishing Authors By Initials

H Yun,S Kim,H Lee,KS Byun,SY Kwon,HJ Yim,YS Lim,SH Jeong,Y Jee,

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Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical virology

VOLUME: 80

Page Numbers: 777-84

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 2

MONTH: May

YEAR: 2008

Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006. Information

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LANGUAGE: eng

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AFFILIATION: Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, Korea National Institute of Health, Seoul, Republic of Korea.

Country: United States

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MEDLINETA: J Med Virol

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