Genetic alteration associated with chronic lymphocytic leukemia.

Genetic alteration associated with chronic lymphocytic leukemia. Research Abstract Details 

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Genetic alteration associated with chronic lymphocytic leukemia. Abstract Text:

F E Cotter,R L Auer,

The genetics of B-cell chronic lymphocytic leukemia (B-CLL) differ considerably from most other forms of hematologic malignancy which are usually characterized by chromosome translocations. B-CLL typically contains chromosomal deletions and chromosomes 13q14 and 11q22-->q23 are the most common. These two regions appear to share a common ancestral origin (Auer et al., 2007b). Overall, chromosomal abnormalities can be found in the majority of patients with B-CLL when using sensitive techniques (Dohneret al., 2000) and possibly reflects an underlying predisposition, with a small but significant number of familial cases. Although single and consistent abnormalities are most common, multiple rearrangements can occur, often with disease progression (Feganetal., 1995; Dohner et al., 2000). Regions of recurrent deletion suggest the presence of tumor suppressor genes if following Knudson's theoretical 2-hit model. However, despite extensive sequencing analysis over the last decade and lack of pathogenic mutations identified, there has been a move away from this suggested hypothesis and alternative mechanisms of gene inactivation involving epigenetic silencing or haploinsufficiency may be considered as more likely in this disease. This review focuses on the common genetic abnormalities in B-CLL and relates them to some of the more recent hypotheses on inactivation of genes within these regions of deletion.

Genetic alteration associated with chronic lymphocytic leukemia. Publishing Authors By Initials

FE Cotter,RL Auer,

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Genetic alteration associated with chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Review

Journal: Cytogenetic and genome research

VOLUME: 118

Page Numbers: 310-9

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ISSN: 1424-859X

DAY: 3

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Genetic alteration associated with chronic lymphocytic leukemia.

AFFILIATION: Centre for Haematology, Institute of Cell and Molecular Sciences, Barts and the London Queen Mary School of Medicine, London, UK. f.e.cotter@qmul.ac.uk

Country: Switzerland

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MEDLINETA: Cytogenet Genome Res

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