Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes.

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Research Abstract Details 

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Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Abstract Text:

Noah C Welker,Jeffrey W Habig,Brenda L Bass,

We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dicer-regulated genes are not dependent on RDE-4 or RDE-1, including the X-linked genes. However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes.

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Publishing Authors By Initials

NC Welker,JW Habig,BL Bass,

For similar cells: cellular structures: chromosomes: sex chromosomes: x chromosome research abstracts see: cells: cellular structures: chromosomes: sex chromosomes: x chromosome research

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Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: RNA (New York, N.Y.)

VOLUME: 13

Page Numbers: 1090-102

Journal Abbreviation: RNA

ISSN: 1355-8382

DAY: 25

MONTH: 05

YEAR: 2007

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9509184

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Keywords Mesh Terms:

KEYWORDS: X Chromosome

MESH TERMS: chemistry

Chemical & Substance for Abstract: Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. Information

Substance Name: Ribonuclease III

Registry Number: EC 3.1.26.3

Grant and Affiliation Information for Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes.

AFFILIATION: Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, 84112, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM067106

ACRONYM: GM

MEDLINETA: RNA

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