Generation of functional hemangioblasts from human embryonic stem cells.

Generation of functional hemangioblasts from human embryonic stem cells. Research Abstract Details 

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Generation of functional hemangioblasts from human embryonic stem cells. Abstract Text:

Shi-Jiang Lu,Qiang Feng,Sergio Caballero,Yu Chen,Malcolm A S Moore,Maria B Grant,Robert Lanza,

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an efficient and reproducible method for generating large numbers of these bipotential progenitors-known as hemangioblasts-from human embryonic stem (hES) cells using an in vitro differentiation system. Blast cells expressed gene signatures characteristic of hemangioblasts, and could be expanded, cryopreserved and differentiated into multiple hematopoietic lineages as well as into endothelial cells. When we injected these cells into rats with diabetes or into mice with ischemia-reperfusion injury of the retina, they localized to the site of injury in the damaged vasculature and appeared to participate in repair. Injection of the cells also reduced the mortality rate after myocardial infarction and restored blood flow in hind limb ischemia in mouse models. Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair.

Generation of functional hemangioblasts from human embryonic stem cells. Publishing Authors By Initials

SJ Lu,Q Feng,S Caballero,Y Chen,MA Moore,MB Grant,R Lanza,

For similar surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research abstracts see: surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research

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Generation of functional hemangioblasts from human embryonic stem cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature methods

VOLUME: 4

Page Numbers: 501-9

Journal Abbreviation: Nat. Methods

ISSN: 1548-7091

DAY: 7

MONTH: 05

YEAR: 2007

Generation of functional hemangioblasts from human embryonic stem cells. Information

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LANGUAGE: eng

NlmUniqueID: 101215604

Generation of functional hemangioblasts from human embryonic stem cells. Keywords Mesh Terms:

KEYWORDS: Stem Cell Transplantation

MESH TERMS: therapy

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Grant and Affiliation Information for Generation of functional hemangioblasts from human embryonic stem cells.

AFFILIATION: Advanced Cell Technology, Worcester, Massachusetts 01605, USA.

Country: United States

AGENCY: United States NEI

GRANT: EY14818

ACRONYM: EY

MEDLINETA: Nat Methods

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