General anesthetics have additive actions on three ligand gated ion channels.

General anesthetics have additive actions on three ligand gated ion channels. Research Abstract Details 

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General anesthetics have additive actions on three ligand gated ion channels. Abstract Text:

BACKGROUND: The purpose of this study was to determine whether pairs of compounds, including general anesthetics, could simultaneously modulate receptor function in a synergistic manner, thus demonstrating the existence of multiple intraprotein anesthetic binding sites. METHODS: Using standard electrophysiologic methods, we measured the effects of at least one combination of benzene, isoflurane (ISO), halothane (HAL), chloroform, flunitrazepam, zinc, and pentobarbital on at least one of the following ligand gated ion channels: N-methyl-d-aspartate receptors, glycine receptors and gamma-aminobutyric acid type A receptors. RESULTS: All drug-drug-receptor combinations were found to exhibit additive, not synergistic modulation. ISO with benzene additively depressed N-methyl-d-aspartate receptors function. ISO with HAL additively enhanced glycine receptors function, as did ISO with zinc. ISO with HAL additively enhanced gamma-aminobutyric acid type A receptors function as did all of the following: HAL with chloroform, pentobarbital with ISO, and flunitrazepam with ISO. CONCLUSION: The simultaneous allosteric modulation of ligand gated ion channels by general anesthetics is entirely additive. Where pairs of general anesthetic drugs interact synergistically to produce general anesthesia, they must do so on systems more complex than a single receptor.

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General anesthetics have additive actions on three ligand gated ion channels. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Anesthesia and analgesia

VOLUME: 107

Page Numbers: 486-93

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 17

MONTH: Aug

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 1310650

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Grant and Affiliation Information for General anesthetics have additive actions on three ligand gated ion channels.

AFFILIATION: Department of Anesthesiology, Emory University School of Medicine, 1462 Clifton Rd NE Suite 420, Atlanta, GA 30322. ajenki2@emory.ed.

Country: United States

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MEDLINETA: Anesth Analg

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