[Gene therapy of ALS with short interfering RNA]

[Gene therapy of ALS with short interfering RNA] Research Abstract Details 

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[Gene therapy of ALS with short interfering RNA] Abstract Text:

Takanori Yokota,Takanori Yokota,

RNA interference (RNAi) is the process of sequence-specific, post-tanscriptional gene silencing, initiated by double-stranded RNA (dsRNA). The gene therapy for familial ALS with siRNA had been started and showed promising results in the model mouse. There is a recent progress in the delivery of siRNA to the central nervous syste. There are still important problems for application of gene therapy including off-target effect and gene delivery of siRNA, but a rapid progress can be expected because of the extremely high efficiency of siRNA.

[Gene therapy of ALS with short interfering RNA] Publishing Authors By Initials

T Yokota,T Yokota,

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PUBLICATION TYPE: Journal Article

Journal: Brain and nerve = Shinkei kenkyū no shinpo

VOLUME: 59

Page Numbers: 1187-94

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ISSN: 1881-6096

DAY: 30

MONTH: Oct

YEAR: 2007

[Gene therapy of ALS with short interfering RNA] Information

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LANGUAGE: jpn

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AFFILIATION: Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

Country: Japan

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MEDLINETA: Brain Nerve

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