Gene therapy in wound healing: present status and future directions.

Gene therapy in wound healing: present status and future directions. Research Abstract Details 

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Gene therapy in wound healing: present status and future directions. Abstract Text:

L K Branski,C T Pereira,D N Herndon,M G Jeschke,

Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.

Gene therapy in wound healing: present status and future directions. Publishing Authors By Initials

LK Branski,CT Pereira,DN Herndon,MG Jeschke,

For similar disorders of environmental origin: wounds and injuries research abstracts see: disorders of environmental origin: wounds and injuries research

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Gene therapy in wound healing: present status and future directions. Journal Published:

PUBLICATION TYPE: Review

Journal: Gene therapy

VOLUME: 14

Page Numbers: 1-10

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 24

MONTH: 08

YEAR: 2006

Gene therapy in wound healing: present status and future directions. Information

Number of References: 100

LANGUAGE: eng

NlmUniqueID: 9421525

Gene therapy in wound healing: present status and future directions. Keywords Mesh Terms:

KEYWORDS: Wounds and Injuries

MESH TERMS: therapy

Chemical & Substance for Abstract: Gene therapy in wound healing: present status and future directions. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Gene therapy in wound healing: present status and future directions.

AFFILIATION: Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA.

Country: England

AGENCY: United States NIGMS

GRANT: T32-GM08256

ACRONYM: GM

MEDLINETA: Gene Ther

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