Gene regulation by transcription factors and microRNAs.

Gene regulation by transcription factors and microRNAs. Research Abstract Details 

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Gene regulation by transcription factors and microRNAs. Abstract Text:

Oliver Hobert,

The properties of a cell are determined by the genetic information encoded in its genome. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most numerous gene regulatory factors in multicellular genomes. Here, I review common principles of transcription factor- and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression.

Gene regulation by transcription factors and microRNAs. Publishing Authors By Initials

O Hobert,

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Gene regulation by transcription factors and microRNAs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 319

Page Numbers: 1785-6

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 28

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. or38@columbia.edu

Country: United States

AGENCY: United States Howard Hugh

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MEDLINETA: Science

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