Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes.

Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Research Abstract Details 

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Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Abstract Text:

Guang Guo,Kirk Wilhelmsen,Nathan Hamilton,

Association analysis has suggested that common sequence variants of genes that affect monoamine function can affect substance use and abuse. Demonstration of these associations has been inconsistent because of limited sample sizes and phenotype definition. Drawing on the life course perspective, we predicted a stronger association between the polymorphisms in 5HTT, DAT1, DRD4, DRD2, and MAOA and alcohol consumption in young adulthood than adolescence. This analysis tested for the gene-lifecourse interaction for the frequency of alcohol consumption in a nationally representative non-alcohol-dependent sample of 2,466 individuals that were visited during adolescence and young adulthood for four times between 1994 and 2002. All five genes are significantly associated with the frequency of alcohol consumption, with the genotype effects ranging 7%-20% of the mean score of alcohol consumption and their P values being 0.014, 0.0003, 0.003, 0.007, 0.005, and 0.003, respectively. The association is only observed in the life stage of young adulthood and not in adolescence. This analysis has demonstrated the potential usefulness of the life course perspective in genetic studies of human behaviors such as alcohol consumption.

Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Publishing Authors By Initials

G Guo,K Wilhelmsen,N Hamilton,

For similar investigative techniques: epidemiologic methods: statistics as topic: regression analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: regression analysis research

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Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 144

Page Numbers: 417-23

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 5

MONTH: Jun

YEAR: 2007

Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235742

Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Keywords Mesh Terms:

KEYWORDS: Regression Analysis

MESH TERMS: metabolism

Chemical & Substance for Abstract: Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Information

Substance Name: Biogenic Monoamines

Registry Number: 0

Grant and Affiliation Information for Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes.

AFFILIATION: Carolina Population Center, University of North Carolina at Chapel Hill, North Carolina 27599-3210, USA. guang_guo@unc.edu

Country: United States

AGENCY: United States NICHD

GRANT: R03-HD042490-02

ACRONYM: HD

MEDLINETA: Am J Med Genet B Neuropsychiat

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