Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress.

Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Research Abstract Details 

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Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Abstract Text:

Tomoko Kawai,Kyoko Morita,Kiyoshi Masuda,Kensei Nishida,Michiyo Shikishima,Masayuki Ohta,Toshiro Saito,Kazuhito Rokutan,

To assess response to chronic psychological stress, gene expression profiles in peripheral blood from 18 medical students confronting license examination were analyzed using an original microarray. Total RNA was collected from each subject 9 months before the examination and mixed to be used as a universal control. At that time, most students had normal scores on the state-trait anxiety inventory (STAI). However, STAI scores were significantly elevated at 2 months and at 2 days before the examination. Pattern of the gene expression profile was more uniform 2 days before than 2 months before the examination. We identified 24 genes that significantly and uniformly changed from the universal control 2 days before the examination. Of the 24 genes, real-time PCR validated changes in mRNA levels of 10 (PLCB2, CSF3R, ARHGEF1, DPYD, CTNNB1, PPP3CA, POLM, IRF3, TP53, and CCNI). The identified genes may be useful to assess chronic psychological stress response.

Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Publishing Authors By Initials

T Kawai,K Morita,K Masuda,K Nishida,M Shikishima,M Ohta,T Saito,K Rokutan,

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Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychology

VOLUME: 76

Page Numbers: 147-55

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ISSN: 0301-0511

DAY: 31

MONTH: 07

YEAR: 2007

Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Information

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LANGUAGE: eng

NlmUniqueID: 375566

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Grant and Affiliation Information for Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress.

AFFILIATION: Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan.

Country: Netherlands

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MEDLINETA: Biol Psychol

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