Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders.

Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Research Abstract Details 

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Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Abstract Text:

Fiona E Craig,Lawrence R Johnson,Stephen A K Harvey,Michael A Nalesnik,Jianhua H Luo,Soumyaroop D Bhattacharya,Steven H Swerdlow,

Although most posttransplant lymphoproliferative disorders (PTLD) are related to Epstein-Barr virus (EBV) infection, approximately 20% lack detectable EBV (EBV-). It is uncertain whether the latter cases are truly distinct from EBV+ PTLD or possibly relate to another infectious agent. This study used gene expression profiling to further investigate the relationship between EBV+ and EBV- monomorphic B-cell PTLD, and to search for clues to their pathogenesis. Affymetrix HU133A GeneChips were used to compare 4 EBV+ and 4 EBV- cases of monomorphic B-cell PTLD. Hierarchical clustering successfully distinguished the EBV+ and EBV- groups. Relative to EBV- PTLD, 54 transcripts were over-expressed in EBV+ PTLD. The transcripts identified included IRF7 (a known regulator of EBV LMP1 expression), EBI2 (EBV-induced gene 2), and 3 that are interferon induced (MX1, IFITM1, and IFITM3). In addition, the EBV+ group contained 232 transcripts decreased relative to the EBV- group, including changes concordant with those previously reported after EBV infection of cultured B-cell lines. In summary, in a small group of monomorphic B-cell PTLD, EBV+ cases demonstrated a subset of gene expression changes associated with EBV infection of B cells. By contrast, EBV- PTLD lacked viral-associated changes suggesting that they are biologically distinct.

Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Publishing Authors By Initials

FE Craig,LR Johnson,SA Harvey,MA Nalesnik,JH Luo,SD Bhattacharya,SH Swerdlow,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Diagnostic molecular pathology : the American jour

VOLUME: 16

Page Numbers: 158-68

Journal Abbreviation: Diagn. Mol. Pathol.

ISSN: 1052-9551

DAY: 3

MONTH: Sep

YEAR: 2007

Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Information

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LANGUAGE: eng

NlmUniqueID: 9204924

Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders.

AFFILIATION: Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. craigfe@upmc.edu

Country: United States

AGENCY: United States NCI

GRANT: P01 CA47445

ACRONYM: CA

MEDLINETA: Diagn Mol Pathol

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