[Gene expression profile in early differentiation of K562 cells induced by matrine]

[Gene expression profile in early differentiation of K562 cells induced by matrine] Research Abstract Details 

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[Gene expression profile in early differentiation of K562 cells induced by matrine] Abstract Text:

Yan Zhang,Ling-Di Ma,Yu-Juan He,Ji-Kai Jiang,

OBJECTIVE: To compare gene expression profile in K562 cells induced by matrine, so as to screen for differentiation related genes. METHODS: K562 cells were exposed to 0.1 mg/ml matrine for 3 hours, and gene expression profiles in matrine-treated and non-treated cells were studied by cDNA microarray. RESULTS: From 8465 screened genes, 30 differentially expressed genes were found. Among them 18 showed decreased expression including oncogene and proto-oncogene, signal transduction gene, DNA binding and transcription gene etc, 12 showed increased expression including cell receptor gene, immune-associated gene, metabolism-associated gene etc in matrine-treated K562 cells as compared with that in non-treated cell. CONCLUSION: The genes, that are closely associated with differentiation of can-cer cell, could be the potential targets for cancer treatment.

[Gene expression profile in early differentiation of K562 cells induced by matrine] Publishing Authors By Initials

Y Zhang,LD Ma,YJ He,JK Jiang,

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[Gene expression profile in early differentiation of K562 cells induced by matrine] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 25

Page Numbers: 342-5

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 13

MONTH: Jun

YEAR: 2004

[Gene expression profile in early differentiation of K562 cells induced by matrine] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Department of Clinical Biochemistry, Chongqing University of Medical Sciences, Chongqing 400016, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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