[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars]

[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars] Research Abstract Details 

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[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars] Abstract Text:

Wei Chen,Xiao-bing Fu,Xiao-qing Sun,Tong-zhu Sun,Zhi-li Zhao,Gang Zhou,Yin-hui Yan,Zhi-yong Sheng,

OBJECTIVE: To explore the change of extracellular-signal regulated protein kinase 1/2 (ERK1/2) and their mitogen activated protein kinase kinases(MAPKKs) gene expression in normal skins versus hypertrophic scars underlying their biological significances. METHODS: After total RNAs were isolated from 8 specimens of hypertrophic scars and 8 specimens of normal skins, and then were purified to mRNAs, the gene expression of ERK1/2 and MEK1/2 were examined with reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: In normal skins, the intensity of gene expression of ERK1/2 and MEK1/2 were weak. In hypertrophic scar, the expression intensities of these 4 genes were 1.1 times, 1.2 times, 2.2 times and 2.5 times of normal skins, respectively. The expression of these 4 genes was significantly elevated in comparison with normal skins. CONCLUSION: The activation of MEK1/2, ERK1/2 gene expression in hypertrophic scars versus in normal skins might be one of the mechanisms controlling the formation of hypertrophic scars.

[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars] Publishing Authors By Initials

W Chen,XB Fu,XQ Sun,TZ Sun,ZL Zhao,G Zhou,YH Yan,ZY Sheng,

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[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 15

Page Numbers: 200-3

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ISSN: 1003-0603

DAY: 14

MONTH: Apr

YEAR: 2003

[Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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Grant and Affiliation Information for [Gene expression of extracellular-signal regulated protein kinase 1/2 and their MAPKKs in hypertrophic scars]

AFFILIATION: 304th Hospital of People's Liberation Army, Beijing 100037, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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