Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp.

Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Research Abstract Details 

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Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Abstract Text:

Tomohiro Yamazoe,Kazuhiro Aoki,Hitoyata Simokawa,Keiichi Ohya,Yuzo Takagi,

Dental pulp self-mineralizes or induces calcified tissue formation, when it is subcutaneously transplanted. This study aims to clarify the nature and process of this tissue calcification by using histochemical techniques and in situ hybridization methods. The dental pulps of incisors from Sprague-Dawley strain rats were homogeneously transplanted into the subcutaneous tissue of the head of another rat. On the 1st day of transplantation, the mRNAs of type I collagen (COL I) and bone sialoprotein (BSP) were expressed in the transplant. On the 5th to 7th days after transplantation, von Kossa-positive, calcified tissues appeared in the transplanted tissues. The mRNAs of COL I, BSP and osteopontin (OPN) were expressed with the same distributions as those of the von Kossa-positive areas, but those of type II collagen (COL II) and bone morphogenic protein 2 (BMP-2) were not expressed in the transplant. When the cellular incorporation of BrdU was examined after its subcutaneous injection into the animals, positive cells were present in the von Kossa-positive calcified foci as well as in their surrounding areas. These results indicate that the transplanted dental pulp possesses the ability to induce cell proliferation resulting in the synthesis of several bone matrix proteins and the formation of calcified tissue. This may give us an insight into the nature and processes of pulp obliteration, which occurs in a human tooth following an episode of trauma.

Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Publishing Authors By Initials

T Yamazoe,K Aoki,H Simokawa,K Ohya,Y Takagi,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medical and dental sciences

VOLUME: 49

Page Numbers: 57-66

Journal Abbreviation: J. Med. Dent. Sci.

ISSN: 1342-8810

DAY: 19

MONTH: Mar

YEAR: 2002

Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Information

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LANGUAGE: eng

NlmUniqueID: 9717112

Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: genetics

Chemical & Substance for Abstract: Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. Information

Substance Name: Bromodeoxyuridine

Registry Number: 59-14-3

Grant and Affiliation Information for Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp.

AFFILIATION: Department of Orofacial Development and Function, Graduate School, Tokyo Medical and Dental University, Japan.

Country: Japan

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MEDLINETA: J Med Dent Sci

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