Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Abstract Text:

Qian Chen,Jeffery T Watson,Susan Ruth Marengo,Keith S Decker,Ilsa Coleman,Peter S Nelson,Robert A Sikes,

Identification of the genes involved in prostate cancer (PCa) progression to a virulent and androgen-independent (AI) form is a major focus in the field. cDNA microarray was used to compare the gene expression profile of the indolent, androgen sensitive (AS) LNCaP PCa cell line to the aggressively metastatic, AI C4-2. Thirty-eight unique sequences from a 6388 cDNA array were found differentially expressed (> or =2-fold, 95% CI). The expression of 14 genes was lower in C4-2 than in LNCaP cells, while the reverse was true for 24 genes. Twelve genes were validated using Q-PCR, Western blotting and immunohistochemistry (IHC) of LNCaP and C4-2 xenograft. Q-PCR showed that 10 of 12 (83.3%) genes had similar patterns of expression to the array (LNCaP>C4-2: TMEFF2, ATP1B1, IL-8, BTG1, BChE, NKX3.1; LNCaP

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Publishing Authors By Initials

Q Chen,JT Watson,SR Marengo,KS Decker,I Coleman,PS Nelson,RA Sikes,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

PUBMED ID PMID:

MEDLINE DATE:

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer letters

VOLUME: 244

Page Numbers: 274-88

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 23

MONTH: 02

YEAR: 2006

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600053

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: metabolism

Chemical & Substance for Abstract: Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo. Information

Substance Name: RNA, Neoplasm

Registry Number: 0

Grant and Affiliation Information for Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.

AFFILIATION: Laboratory for Cancer Ontogeny and Therapeutics, Department of Biological Sciences, University of Delaware, Wolf Hall, Newark, DE 19716, USA.

Country: Ireland

AGENCY: United States NIDDK

GRANT: R21 DK62073

ACRONYM: DK

MEDLINETA: Cancer Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo Related Publications

• A comparison of rheumatoid-like arthritis in swine and rheumatoid arthritis in man.
• Aseptic meningitis associated with chronic sulindac use for osteoarthritis: a case report.
• Burned-out, or forced out?
• Chemistry and pharmacology of anticancer drugs.
• Comparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine.
• Differential Activation of Dual Promoters Alters D{beta}2 Germline Transcription during Thymocyte Development.
• Effect of repeated flushing and a prostaglandin analogue on the estrous cycle of pony mares.
• Eletriptan for the treatment of migraine in patients with previous poor response or tolerance to oral sumatriptan.
• Eletriptan in the early treatment of acute migraine: influence of pain intensity and time of dosing.
• Experimental production of bovine hyperkeratosis with a feed concentrate exposed to vapors of a highly chlorinated naphthalene.
• Frenquel corrects EEG changes and relieves symptoms in porphyria.
• Gene expression in the LNCaP human prostate cancer progression model: progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo.
• Gouty glycosuria.
• Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model.
• Laboratory techniques in rabies: the antibody binding test for vaccine potency.
• Patient satisfaction with eletriptan in the acute treatment of migraine in primary care.
• Preparation of antirabies immunoglobulin of human origin.
• Sensitivity studies with repeated intradermal Johnin tests in cattle naturally infected with Mycobacterium Paratuberculosis; Johne's disease.
• Stiff-man syndrome; analysis and case report with spinal cord autopsy.
• The incidence of arthritis in swine following vaccination for swine erysipelas.
• Use of the oral mercurial diuretics in advanced congestive heart failure.
• Voltage-sensitive ion channels and cancer.