Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease.

Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Research Abstract Details 

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Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Abstract Text:

Meena Thayu,Justine Shults,Jon M Burnham,Babette S Zemel,Robert N Baldassano,Mary B Leonard,Meena Thayu,Justine Shults,Jon M Burnham,Babette S Zemel,Robert N Baldassano,Mary B Leonard,

BACKGROUND: Childhood Crohn's disease (CD) is associated with poor growth and decreased body mass index (BMI); however, lean mass (LM) and fat mass (FM) deficits prior to therapy have not been characterized.Objectives: To quantify LM and FM in incident pediatric CD subjects and controls, and to identify determinants of LM and FM deficits. METHODS: Whole body LM and FM were assessed using DXA in 78 CD subjects and 669 healthy controls, ages 5-21 yr. Gender specific z-scores for LM (LM-Ht) and FM (FM-Ht) relative to height were derived using log linear regression models in the controls. Multivariate linear regression models adjusted for potential confounders. RESULTS: CD was associated with significantly lower height and BMI for age. Within CD subjects, FM-Ht and LM-Ht were significantly lower in females compared with males (FM-Ht z: -0.66+/-0.83 vs. -0.08+/-0.95, p<0.01; LM-Ht z: -1.12+/-1.12 vs. -0.57+/-0.99, p<0.05). In females, CD was associated with significantly lower LM-Ht (p<0.001) and FM-Ht (p=0.001), adjusted for age, race and Tanner stage, compared with controls. LM and FM deficits were significantly greater in older females with CD; 47% of adolescent females had LM-Ht

Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Publishing Authors By Initials

M Thayu,J Shults,JM Burnham,BS Zemel,RN Baldassano,MB Leonard,M Thayu,J Shults,JM Burnham,BS Zemel,RN Baldassano,MB Leonard,

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Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inflammatory bowel diseases

VOLUME: 13

Page Numbers: 1121-8

Journal Abbreviation: Inflamm. Bowel Dis.

ISSN: 1078-0998

DAY: 9

MONTH: Sep

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Children's Hospital of Philadelphia-Gastroenterology, Hepatology, and Nutrition, Philadelphia, Pennsylvania 19104, USA. thayu@email.chop.edu

Country: United States

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MEDLINETA: Inflamm Bowel Dis

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