Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome.

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Research Abstract Details 

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Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Abstract Text:

Heather M Mattern,Pamela G Lloyd,Michael Sturek,Christopher D Hardin,

The metabolic syndrome and diabetes are associated with bladder dysfunction in many people. Peroxisome proliferator-activated receptors (PPARs) may play a role in the effects of the metabolic syndrome on bladder smooth muscle (BSM). The purpose of this study was to determine if there are gender and genetic differences in PPAR levels in BSM. We measured PPAR levels using quantitative PCR in BSM from male Yucatan swine and male and female Ossabaw Island swine, which is a model for the metabolic syndrome. Male Ossabaw swine had 0.732 +/- 0.111 the amount of PPAR-alpha mRNA as male Yucatan swine (P < 0.05), suggesting a genetic difference in PPAR-alpha levels. This difference may possibly contribute to the incidence of metabolic syndrome in the Ossabaw model compared to the Yucatan model. PPAR-delta mRNA was 2-fold higher in male Ossabaw swine than in female Ossabaw swine, with no significant differences in PPAR-alpha levels. However, PPAR-gamma mRNA was 4.067 +/- 0.134 times higher in female Ossabaw swine than in their male counterparts (P < 0.001). Changing the percentage of calories derived from fat did not alter any PPAR mRNA levels. Thus, PPAR-delta and PPAR-gamma mRNA levels in male and female Ossabaw swine BSM are not only different, but may also result in gender differences in lipid metabolism in bladder smooth muscle. We conclude that PPAR profiles in BSM may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Publishing Authors By Initials

HM Mattern,PG Lloyd,M Sturek,CD Hardin,

For similar urogenital system: urinary tract: urinary bladder research abstracts see: urogenital system: urinary tract: urinary bladder research

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Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and cellular biochemistry

VOLUME: 302

Page Numbers: 43-9

Journal Abbreviation: Mol. Cell. Biochem.

ISSN: 0300-8177

DAY: 21

MONTH: 02

YEAR: 2007

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 364456

Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder

MESH TERMS: metabolism

Chemical & Substance for Abstract: Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome.

AFFILIATION: Department of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, Columbia, MO 65212, USA.

Country: Netherlands

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MEDLINETA: Mol Cell Biochem

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