Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma.

Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma. Research Abstract Details 

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Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma. Abstract Text:

Kazumasa Matsumoto,Akira Irie,Takefumi Satoh,Miyoko Okazaki,Masatsugu Iwamura,Shiro Baba,Kazumasa Matsumoto,Akira Irie,Takefumi Satoh,Miyoko Okazaki,Masatsugu Iwamura,Shiro Baba,

OBJECTIVES: We report that a combination of gemcitabine and paclitaxel will effectively treat patients with advanced urothelial carcinoma (UC) who have been previously treated with methotrexate, vinblastine, adriamycin, and cisplatin (MVAC). The objective of this study was to assess the tumor responses, toxicity, and overall survival of these patients as second-line treatment. METHODS: Ten eligible patients were enrolled in this study. All patients had been previously treated with MVAC. Patients received paclitaxel 200 mg/m(2) on day 1 and gemcitabine 1000 mg/m(2) on days 1, 8, and 15. The treatment was repeated every 21 days. Tumors were assessed every two cycles by imaging study. RESULTS: The median number of treatment courses was 4 (range 2-7). Two patients had complete response and five patients had partial response after two courses of treatment. Median overall survival was 10.3 months. Median overall survival from the first MVAC was 19.1 months. Median progression-free survival was 4.1 months. Of the seven responders, median progression-free survival was 7.4 months. Myelosuppression was the most common toxicity. Nonhematologic toxicity consisted of hypersensitivity reactions to paclitaxel. There were no therapy-related deaths. CONCLUSIONS: Gemcitabine and paclitaxel chemotherapy is a favorable therapeutic alternative for patients with advanced or metastatic UC who have previously been treated with MVAC chemotherapy. Given the safety and benefit profile seen in this study, a large prospective research study is warranted to consider the potential role of gemcitabine and paclitaxel chemotherapy as a second-line treatment for urothelial cancer.

Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma. Publishing Authors By Initials

K Matsumoto,A Irie,T Satoh,M Okazaki,M Iwamura,S Baba,K Matsumoto,A Irie,T Satoh,M Okazaki,M Iwamura,S Baba,

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Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of urology : official journa

VOLUME: 14

Page Numbers: 1000-4; discussion 1004

Journal Abbreviation: Int. J. Urol.

ISSN: 0919-8172

DAY: 24

MONTH: Nov

YEAR: 2007

Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Gemcitabine and paclitaxel chemotherapy as a second-line treatment for advanced or metastatic urothelial carcinoma.

AFFILIATION: Department of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, Japan. kazumasa@cd5.so-net.ne.jp

Country: Australia

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MEDLINETA: Int J Urol

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