Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions.

Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Research Abstract Details 

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Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Abstract Text:

M Brant-Zawadzki,I Berry,L Osaki,R Brasch,J Murovic,D Norman,

Over 35 intraaxial lesions in 15 patients suspected of having intracranial tumors were studied with MR before and after injection of Gadolinium-DTPA (Gd-DTPA). Diseases included primary and metastatic brain tumors, plaques of multiple sclerosis, occult arteriovenous malformations, lymphoma, toxoplasmosis, and pituitary adenoma. The precontrast T2-weighted sequence (SE 2000/30, 60) was found to be most sensitive in detecting intraaxial lesions, showing 17 lesions that were not seen on the post-Gd-DTPA T1-weighted sequence (SE 500/30). In one case of multiple sclerosis, several lesions seen on the pre-Gd-DTPA study on T2-weighted images faded after injection of Gd-DTPA (due to T2 shortening). In two patients with large metastatic foci, other small metastatic lesions were seen better after Gd-DTPA on both T1- and T2-weighted sequences. Four other patients with only one focal-enhancing lesion and one patient with multifocal lesions on T1-weighted images actually had a much larger single glioma depicted on pre-Gd-DTPA T2-weighted images. In a patient with AIDS, a ring-enhancing lesion thought to be an abscess proved to be lymphoma. The cryptic arteriovenous malformations enhanced but showed more characteristic findings, such as hemorrhage, on pre-Gd-DTPA studies. Our experience suggests that Gd-DTPA may not improve sensitivity of MR in the detection of intraaxial lesions. However, functional aspects of brain disease, such as the presence of perfusion of a lesion and active breach of the blood-brain barrier, are depicted well with Gd-DTPA and are vital for proper diagnosis in many instances.

Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Publishing Authors By Initials

M Brant-Zawadzki,I Berry,L Osaki,R Brasch,J Murovic,D Norman,

For similar organic chemicals: amines: polyamines: pentetic acid research abstracts see: organic chemicals: amines: polyamines: pentetic acid research

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Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJR. American journal of roentgenology

VOLUME: 147

Page Numbers: 1223-30

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Dec

YEAR: 1986

Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Keywords Mesh Terms:

KEYWORDS: Pentetic Acid

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Gd-DTPA in clinical MR of the brain: 1. Intraaxial lesions. Information

Substance Name: Pentetic Acid

Registry Number: 67-43-6

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Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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