Gd-DTPA enhancement of posterior epidural scar: an experimental model.

Gd-DTPA enhancement of posterior epidural scar: an experimental model. Research Abstract Details 

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Gd-DTPA enhancement of posterior epidural scar: an experimental model. Abstract Text:

J S Ross,S Blaser,T J Masaryk,S E Emory,M Bolesta,J Carter,M Aikawa,M T Modic,

Because of the tremendous clinical and physiological importance of anterior epidural scar, an easily produced and reproducible model to assess potential pathways for lessening its formation is a necessity. We speculated whether posterior epidural scar (produced by the less complex surgery of laminectomy alone) could be considered equivalent to anterior scar from an imaging standpoint; that is, enhancement following Gd-DTPA irrespective of scar age. Posterior epidural scar in dogs showed the highest degree of enhancement 1 month after surgery, with a rapid decline thereafter out to 4 months postsurgery to a level equivalent to that of paraspinal muscle. Gd-153-DTPA time/activity curves paralleled the Gd-DTPA findings. Light microscopy showed granulation tissue after 1 month, and mature scar with large amounts of collagen 4 months after surgery. Electron microscopy showed tight capillary endothelial junctions. An appropriate model for epidural scar, which has imaging characteristics similar to human anterior scar, necessitates an extensive lumbar laminectomy with anterior epidural dissection. A simple laminectomy, while easily performed, does not provide a physiologically correct time course of enhancement.

Gd-DTPA enhancement of posterior epidural scar: an experimental model. Publishing Authors By Initials

JS Ross,S Blaser,TJ Masaryk,SE Emory,M Bolesta,J Carter,M Aikawa,MT Modic,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Gd-DTPA enhancement of posterior epidural scar: an experimental model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 10

Page Numbers: 1083-8

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: 02

YEAR: 2008

Gd-DTPA enhancement of posterior epidural scar: an experimental model. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

Gd-DTPA enhancement of posterior epidural scar: an experimental model. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: pathology

Chemical & Substance for Abstract: Gd-DTPA enhancement of posterior epidural scar: an experimental model. Information

Substance Name: Gadolinium DTPA

Registry Number: 80529-93-7

Grant and Affiliation Information for Gd-DTPA enhancement of posterior epidural scar: an experimental model.

AFFILIATION: Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, OH 44106.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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