Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast.

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Abstract Text:

Qiuju Han,Jun Lu,Jizhou Duan,Dongmei Su,Xiaozhe Hou,Fen Li,Xiuli Wang,Baiqu Huang,Qiuju Han,Jun Lu,Jizhou Duan,Dongmei Su,Xiaozhe Hou,Fen Li,Xiuli Wang,Baiqu Huang,Qiuju Han,Jun Lu,Jizhou Duan,Dongmei Su,Xiaozhe Hou,Fen Li,Xiuli Wang,Baiqu Huang,

The purpose of this study was to elucidate the mechanisms by which histone acetylation participates in transcriptional regulation of hsp70 (heat-shock protein 70) genes SSA3 and SSA4 in yeast. Our results indicated that histone acetylation was required for the transcriptional activation of SSA3 and SSA4. The HATs (histone acetyltransferases) Gcn5 (general control non-derepressible 5) and Elp3 (elongation protein 3) modulated hsp70 gene transcription by affecting the acetylation status of histone H3. Although the two HATs possessed overlapping function regarding the acetylation of histone H3, they affected hsp70 gene transcription in different ways. The recruitment of Gcn5 was Swi/Snf-dependent and was required for HSF (heat-shock factor) binding and affected RNAPII (RNA polymerase II) recruitment, whereas Elp3 exerted its roles mainly through affecting RNAPII elongation. These results provide insights into the effects of Gcn5 and Elp3 in hsp70 gene transcription and underscore the importance of histone acetylation for transcriptional initiation and elongation in hsp genes.

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Publishing Authors By Initials

Q Han,J Lu,J Duan,D Su,X Hou,F Li,X Wang,B Huang,Q Han,J Lu,J Duan,D Su,X Hou,F Li,X Wang,B Huang,Q Han,J Lu,J Duan,D Su,X Hou,F Li,X Wang,B Huang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Biochemical journal

VOLUME: 409

Page Numbers: 779-88

Journal Abbreviation: Biochem. J.

ISSN: 1470-8728

DAY: 1

MONTH: Feb

YEAR: 2008

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984726

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast.

AFFILIATION: Key Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast Related Publications

• Clinicopathological observation of renal adenomas.
• Effects of the central amygdaloid nucleus lesions on the gustatory responses in the parabrachial nucleus in rats.
• Ehlers-Danlos syndrome: case and pedigree report and review.
• Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases.
• [A rapid and simple detection of DNA fragment with point mutation by capillary electrophoresis]
• [A simple and rapid new method for SNP typing by single-tube bi-directional allele specific amplification]
• [Algorithms of multiband remote sensing for coastal red tide waters]
• [Analysis of factors correlated to death and reinfarction in patients with acute myocardial infarction]
• [Application of liposuction in scar repair]
• [Biomechanical evaluation of the stability of General spine system]
• [Clinical analysis of combined resection for T4 gastric cancer: report of 69 cases]
• [Determination of residues of organic chloride pesticide in Chinese Medicinal materials with capillary gas chromatography]
• [Ecological characteristics of Prorocentrum dentatum and the cause of harmful algal bloom formation in China Sea]
• [Effect of intracerebroventricular injection of histamine on carotid sinus baroreceptor reflex in anesthetized rats and its mechanism]
• [Experience with cardioventer defibrillator therapy in 113 patients]
• [Lower back pain in truck drivers working in plateau areas and its prevention]
• [Mammographic findings of gynecomastia]
• [Miniature quadrupole mass spectrometer array and its applications in manned spaceflight]
• [Molecular identification of human/goat xenogeneic model]
• [Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line]
• [Protective effects of c-jun anti-sense gene recombinant transfection on rat cardiomyocytes inflicted by hypoxia and burn serum]
• [Purification and stability studies of prokaryotic PDCD5 protein]
• [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]
• [Repair of facial defect with expanded skin flap from medial upper arm]
• [Secondary reconstruction of post-fracture deformities in the nasal-orbital ethmoid region]
• [Study on morphological change in intestinal mucosa from injury to repair after hemorrhagic shock]
• [Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats]
• [The correlations between glucocorticoid receptor of lymphocyte and immune function]
• [The reason and prevention of upper cervical reoperations]
• [The relation and evaluation of the vertebral artery and the nerve root to posterior lateral mass screw fixation]