GATA factors participate in tissue-specific immune responses in Drosophila larvae.

GATA factors participate in tissue-specific immune responses in Drosophila larvae. Research Abstract Details 

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GATA factors participate in tissue-specific immune responses in Drosophila larvae. Abstract Text:

Kate Senger,Kristina Harris,Mike Levine,

Drosophila responds to infection by producing a broad range of antimicrobial agents in the fat body and more restricted responses in tissues such as the gut, trachea, and malpighian tubules. The regulation of antimicrobial genes in larval fat depends on linked Rel/NF-kappaB and GATA binding sites. Serpent functions as the major GATA transcription factor in the larval fat body. However, the transcriptional regulation of other tissue-specific responses is less well understood. Here, we present evidence that dGATAe regulates antimicrobial gene expression in the midgut. Regulatory regions for antimicrobial genes Diptericin and Metchnikowin require GATA sites for activation in the midgut, where Grain (dGATAc), dGATAd, and dGATAe are expressed in overlapping domains. Ectopic expression of dGATAe in the larval fat body, where it is normally absent, causes dramatic up-regulation of numerous innate immunity and gut genes, as judged by microarray analysis and in situ hybridization. Ectopic dGATAe also causes a host of symptoms reminiscent of hyperactive Toll (Toll(10b)) mutants, but without apparent activation of Toll signaling. Based on this evidence we propose that dGATAe mediates a Toll-independent immune response in the midgut, providing a window into the first and perhaps most ancient line of animal defense.

GATA factors participate in tissue-specific immune responses in Drosophila larvae. Publishing Authors By Initials

K Senger,K Harris,M Levine,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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GATA factors participate in tissue-specific immune responses in Drosophila larvae. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 15957-62

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 10

MONTH: 10

YEAR: 2006

GATA factors participate in tissue-specific immune responses in Drosophila larvae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

GATA factors participate in tissue-specific immune responses in Drosophila larvae. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: immunology

Chemical & Substance for Abstract: GATA factors participate in tissue-specific immune responses in Drosophila larvae. Information

Substance Name: GATA Transcription Factors

Registry Number: 0

Grant and Affiliation Information for GATA factors participate in tissue-specific immune responses in Drosophila larvae.

AFFILIATION: Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720-3204, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM46638

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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