GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model.

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Research Abstract Details 

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GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Abstract Text:

Hosein Kouros-Mehr,Seth K Bechis,Euan M Slorach,Laurie E Littlepage,Mikala Egeblad,Andrew J Ewald,Sung-Yun Pai,I-Cheng Ho,Zena Werb,Hosein Kouros-Mehr,Seth K Bechis,Euan M Slorach,Laurie E Littlepage,Mikala Egeblad,Andrew J Ewald,Sung-Yun Pai,I-Cheng Ho,Zena Werb,

How breast cancers are able to disseminate and metastasize is poorly understood. Using a hyperplasia transplant system, we show that tumor dissemination and metastasis occur in discrete steps during tumor progression. Bioinformatic analysis revealed that loss of the transcription factor GATA-3 marked progression from adenoma to early carcinoma and onset of tumor dissemination. Restoration of GATA-3 in late carcinomas induced tumor differentiation and suppressed tumor dissemination. Targeted deletion of GATA-3 in early tumors led to apoptosis of differentiated cells, indicating that its loss is not sufficient for malignant conversion. Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer.

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Publishing Authors By Initials

H Kouros-Mehr,SK Bechis,EM Slorach,LE Littlepage,M Egeblad,AJ Ewald,SY Pai,IC Ho,Z Werb,H Kouros-Mehr,SK Bechis,EM Slorach,LE Littlepage,M Egeblad,AJ Ewald,SY Pai,IC Ho,Z Werb,

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GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer cell

VOLUME: 13

Page Numbers: 141-52

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 4

MONTH: Feb

YEAR: 2008

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model. Information

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LANGUAGE: eng

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AFFILIATION: Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA; The Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA.

Country: United States

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MEDLINETA: Cancer Cell

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