Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Abstract Text:

Florian Rieder,Ling Cheng,Karen M Harnett,Amitabh Chak,Gregory S Cooper,Gerard Isenberg,Monica Ray,Jeffry A Katz,Andrew Catanzaro,Robert O'Shea,Anthony B Post,Richard Wong,Michael V Sivak,Thomas McCormick,Manijeh Phillips,Gail A West,Joseph E Willis,Piero Biancani,Claudio Fiocchi,

BACKGROUND & AIMS: Gastroesophageal reflux disease is a condition frequently associated with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory cytokines, such as interleukin (IL)-1beta and IL-6, may be implicated because they reduce esophageal muscle contractility, but these results derive from in vitro or animal models of esophagitis. This study used human esophageal cells and tissues to identify the cellular source of cytokines in human esophagitis investigate whether cytokines can be induced by gastric refluxate, and examine whether esophageal tissue- or cell-derived mediators affect muscle contractility. METHODS: Endoscopic mucosal biopsy specimens were obtained from patients with and without esophagitis, organ-cultured, and undernatants were assessed for cytokine content. The cytokine profile of esophageal epithelial, fibroblast, and muscle cells was analyzed, and esophageal mucosa and cell products were tested in an esophageal circular muscle contraction assay. RESULTS: The mucosa of esophagitis patients produced significantly greater amounts of IL-1beta and IL-6 compared with those of control patients. Cultured esophageal epithelial cells produced IL-6, as did fibroblasts and muscle cells. Epithelial cells exposed to buffered, but not denatured, gastric juice produced IL-6. Undernatants of mucosal biopsy cultures from esophagitis patients reduced esophageal muscle contraction, as did supernatants from esophageal epithelial cell cultures. CONCLUSIONS: The human esophagus produces cytokines capable of reducing contractility of esophageal muscle cells. Exposure to gastric juice is sufficient to stimulate esophageal epithelial cells to produce IL-6, a cytokine able to alter esophageal contractility. These results indicate that classic cytokines are important mediators of the motor disturbances associated with human esophageal inflammation.

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Publishing Authors By Initials

F Rieder,L Cheng,KM Harnett,A Chak,GS Cooper,G Isenberg,M Ray,JA Katz,A Catanzaro,R O'Shea,AB Post,R Wong,MV Sivak,T McCormick,M Phillips,GA West,JE Willis,P Biancani,C Fiocchi,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

PUBMED ID PMID:

MEDLINE DATE:

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gastroenterology

VOLUME: 132

Page Numbers: 154-65

Journal Abbreviation: Gastroenterology

ISSN: 0016-5085

DAY: 12

MONTH: 10

YEAR: 2006

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374630

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: metabolism

Chemical & Substance for Abstract: Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.

AFFILIATION: Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Country: United States

AGENCY: United States NIDDK

GRANT: DK 57030

ACRONYM: DK

MEDLINETA: Gastroenterology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities Related Publications

• Anaphylaxis in the emergency department: a paediatric perspective.
• Angiogenesis blockade as a new therapeutic approach to experimental colitis.
• Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.
• Immune events associated with inflammatory bowel disease.
• Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation.
• Inflammatory bowel disease: progress and current concepts of etiopathogenesis.
• Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science.
• Lymphoid cells of the gastrointestinal tract. Isolation procedures.
• Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease.
• [Recognizing anaphylaxis in the emergency department]