Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection?

Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Research Abstract Details 

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Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Abstract Text:

C B Lamers,

Hypersecretion of gastric acid, gastrin, and pepsinogen are considered to be causally related to duodenal ulcer diathesis. Until recently, these abnormalities have been considered to be primary and largely genetically determined. However, Helicobacter pylori infection has been shown to be responsible for several of the abnormalities of gastric secretion in duodenal ulcer. H. pylori infection is not only associated with chronic active inflammation but also with a reduction of somatostatin producing D-cells and somatostatin concentrations in the gastric mucosa. The reduced inhibitory action of somatostatin on the secretion of gastric acid, gastrin, and pepsinogen may be responsible for the hypersecretory state of the stomach in duodenal ulcer. These recent findings have drastically changed our understanding of the pathogenesis of duodenal ulcer.

Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Publishing Authors By Initials

CB Lamers,

For similar enzymes and coenzymes: enzyme precursors: pepsinogens research abstracts see: enzymes and coenzymes: enzyme precursors: pepsinogens research

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Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 194

Page Numbers: 99-103

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1992

Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Information

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LANGUAGE: eng

NlmUniqueID: 437034

Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Keywords Mesh Terms:

KEYWORDS: Pepsinogens

MESH TERMS: secretion

Chemical & Substance for Abstract: Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection? Information

Substance Name: Pepsinogens

Registry Number: 0

Grant and Affiliation Information for Gastric secretory abnormalities in duodenal ulcer: primary or secondary to Helicobacter pylori infection?

AFFILIATION: Dept. of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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